A CRISPR-Based Screen Identifies Genes Essential for West-Nile-Virus-Induced Cell Death

A CRISPR-Based Screen Identifies Genes Essential for West-Nile-Virus-Induced Cell Death

West Nile virus (WNV) causes an acute neurological infection attended by massive neuronal cell death. However, the mechanism(s) behind the virus-induced cell death is poorly understood. Using a library containing 77,406 sgRNAs targeting 20,121 genes, we performed a genome-wide screen followed by a s...

Full description

Bibliographic Details
Main Authors: Hongming Ma, Ying Dang, Yonggan Wu, Gengxiang Jia, Edgar Anaya, Junli Zhang, Sojan Abraham, Jang-Gi Choi, Guojun Shi, Ling Qi, N. Manjunath, Haoquan Wu
Format: Article
Language:English
Published: Elsevier 2015-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715006750

Similar Items

Similar Items