4-Arylthieno[2,3-<i>b</i>]pyridine-2-carboxamides Are a New Class of Antiplasmodial Agents

4-Arylthieno[2,3-<i>b</i>]pyridine-2-carboxamides Are a New Class of Antiplasmodial Agents

Malaria causes hundreds of thousands of deaths every year, making it one of the most dangerous infectious diseases worldwide. Because the pathogens have developed resistance against most of the established anti-malarial drugs, new antiplasmodial agents are urgently needed. In analogy to similar anti...

Full description

Bibliographic Details
Main Authors:	Sandra I. Schweda, Arne Alder, Tim Gilberger, Conrad Kunick
Format:	Article
Language:	English
Published:	MDPI AG 2020-07-01
Series:	Molecules
Subjects:	anti-malarial drugs antiplasmodial malaria <i>Pf</i>GSK-3 <i>Plasmodium falciparum</i> thieno[2,3-<i>b</i>]pyridine
Online Access:	https://www.mdpi.com/1420-3049/25/14/3187

Similar Items

Structure–activity relationships in a series of antiplasmodial thieno[2,3-b]pyridines
by: Andreas Masch, et al.
Published: (2019-03-01)

Synthesis of Novel Methyl 3-(hetero)arylthieno[3,2-<i>b</i>]pyridine-2-carboxylates and Antitumor Activity Evaluation: Studies In Vitro and In Ovo Grafts of Chick Chorioallantoic Membrane (CAM) with a Triple Negative Breast Cancer Cell Line
by: Bruna R. Silva, et al.
Published: (2021-03-01)

Synthesis of Novel Analogs of Thieno[2,3-<i>d</i>] Pyrimidin-4(3<i>H</i>)-ones as Selective Inhibitors of Cancer Cell Growth
by: Sheng Zhang, et al.
Published: (2019-10-01)

<b>Antiplasmodial and larvicidal flavonoids from <i>Derris trifoliate</i></b>
by: Abiy Yenesew, et al.
Published: (2009-12-01)

4-(3-Phenyl-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidin-1-yl)thieno[3,2-<i>d</i>]pyrimidine
by: Eun Sun Noh, et al.
Published: (2020-05-01)

In Vitro Assessment of Antiplasmodial and Antitrypanosomal Activities of Chloroform, Ethyl Acetate and Ethanol Leaf Extracts of <i>Oedera genistifolia</i>
by: Kunle Okaiyeto, et al.
Published: (2020-10-01)

Antiplasmodial and Cytotoxic Flavonoids from <i>Pappea capensis</i> (Eckl. & Zeyh.) Leaves
by: Nasir Tajuddeen, et al.
Published: (2021-06-01)

Antiplasmodial Compounds from Deep-Water Marine Invertebrates
by: Amy E. Wright, et al.
Published: (2021-03-01)

Regular and Intra-Regular Semigroups in Terms of <i>m</i>-Polar Fuzzy Environment
by: Shahida Bashir, et al.
Published: (2021-08-01)

Bioactivities of Lyngbyabellins from Cyanobacteria of <i>Moorea </i>and <i>Okeania </i>Genera
by: Imam Fathoni, et al.
Published: (2020-09-01)

In Vitro Antiplasmodial and Cytotoxic Activities of Compounds from the Roots of <i>Eriosema montanum Baker f.</i> (Fabaceae)
by: Jean Claude Didelot Tomani, et al.
Published: (2021-05-01)

Novel Harmicines with Improved Potency against <i>Plasmodium</i>
by: Marina Marinović, et al.
Published: (2020-09-01)

<i>A</i> New Benzopyranyl Cadenane Sesquiterpene and Other Antiplasmodial and Cytotoxic Metabolites from <i>Cleistochlamys kirkii</i>
by: Stephen S. Nyandoro, et al.
Published: (2019-07-01)

Thieno[2,3-<i>b</i>]Pyridine Derivative Targets Epithelial, Mesenchymal and Hybrid CD15s<sup>+</sup> Breast Cancer Cells
by: Sandra Marijan, et al.
Published: (2021-06-01)

Novel Conjugated Polymers Containing 3-(2-Octyldodecyl)thieno[3,2-<i>b</i>]thiophene as a π-Bridge for Organic Photovoltaic Applications
by: Jong-Woon Ha, et al.
Published: (2020-09-01)

<i>N′</i>-Acetyl-3-methyl-1,6-diphenyl-1<i>H</i>-pyrazolo[3,4-<i>b</i>]pyridine-4-carbohydrazide
by: Júlio C. A. V. Soares, et al.
Published: (2020-01-01)

Ammonium Salts of 5-(3-Chromenyl)-5<i>H</i>-chromeno[2,3-<i>b</i>]pyridines
by: Yuliya E. Ryzhkova, et al.
Published: (2021-05-01)

1-(Imidazo[1,2-<i>a</i>]pyridin-1-ium-1-yl)-2,3,4-trioxocyclobutan-1-ide
by: Johann Grünefeld, et al.
Published: (2019-07-01)

Silencing of <i>HvGSK1.1</i>—A GSK3/SHAGGY-Like Kinase–Enhances Barley (<i>Hordeum vulgare</i> L.) Growth in Normal and in Salt Stress Conditions
by: Yuliya Kloc, et al.
Published: (2020-09-01)

Affinity of Antifungal Isoxazolo[3,4-<i>b</i>]pyridine-3(1<i>H</i>)-Ones to Phospholipids in Immobilized Artificial Membrane (IAM) Chromatography
by: Krzesimir Ciura, et al.
Published: (2020-10-01)

Phytochemistry, Traditional Use and Pharmacological Activity of <i>Picrasma quassioides</i>: A Critical Reviews
by: Muhammad Daniel Hakim Mohd Jamil, et al.
Published: (2020-08-01)

The Crystal Structure of the <i>Plasmodium falciparum</i> PdxK Provides an Experimental Model for Pro-Drug Activation
by: Kai Gao, et al.
Published: (2019-10-01)

Synthesis, Antitumor Activity, and Docking Analysis of New Pyrido[3′,2′:4,5]furo(thieno)[3,2-<i>d</i>]pyrimidin-8-amines
by: Samvel N. Sirakanyan, et al.
Published: (2019-10-01)

<i>CRKL</i>, <i>AIFM3</i>, <i>AIF</i>, <i>BCL2</i>, and <i>UBASH3A</i> during Human Kidney Development
by: Mirela Lozic, et al.
Published: (2021-08-01)

Natural Compounds and Their Structural Analogs in Regio- and Stereoselective Synthesis of New Families of Water-Soluble 2<i>H</i>,3<i>H</i>-[1,3]thia- and -Selenazolo[3,2-<i>a</i>]pyridin-4-ium Heterocycles by Annulation Reactions
by: Vladimir A. Potapov, et al.
Published: (2020-01-01)

<i>AtSK11</i> and <i>AtSK12</i> Mediate the Mild Osmotic Stress-Induced Root Growth Response in <i>Arabidopsis</i>
by: Long Dong, et al.
Published: (2020-06-01)

Alcohol Participates in the Synthesis of Functionalized Coumarin-Fused Pyrazolo[3,4-<i>b</i>]Pyridine from a One-Pot Three-Component Reaction
by: Wei Lin, et al.
Published: (2019-08-01)

Synthesis of some new Thieno[2,3-b]pyridines, Pyrimidino[4',5':4,5]thieno[2,3-b]pyridine and Pyridines Incorporating 5-Bromobenzofuran-2-yl Moiety
by: Nadia Abdelhamed Abdelriheem, et al.
Published: (2015-01-01)

Synthesis and Biological Evaluation of New Antitubulin Agents Containing 2-(3′,4′,5′-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3-<i>c</i>]pyridine Scaffold
by: Romeo Romagnoli, et al.
Published: (2020-04-01)

5-(Indol-2-yl)pyrazolo[3,4-<i>b</i>]pyridines as a New Family of TASK-3 Channel Blockers: A Pharmacophore-Based Regioselective Synthesis
by: David Ramírez, et al.
Published: (2021-06-01)

8,18-Dithia-1,4,11,14-tetraazapentacyclo[11.7.0.0<sup>3,11</sup>.0<sup>5,9</sup>.0<sup>15,19</sup>]icosa-3,5(9),6,13,15(19),16-hexaene-10,20-dione
by: Vladimir A. Ogurtsov, et al.
Published: (2019-04-01)

Integrative Role of <i>14-3-3ε</i> in Sleep Regulation
by: Yu Wei, et al.
Published: (2021-09-01)

The Impact of ALS-Associated Genes <i>hnRNPA1</i>, <i>MATR3</i>, <i>VCP</i> and <i>UBQLN2</i> on the Severity of TDP-43 Aggregation
by: Ana Bajc Česnik, et al.
Published: (2020-07-01)

Dual Anti-Malarial and GSK3β-Mediated Cytokine-Modulating Activities of Quercetin Are Requisite of Its Potential as a Plant-Derived Therapeutic in Malaria
by: Amatul Hamizah Ali, et al.
Published: (2021-03-01)

Biochemical Characterization of a Flavonoid <i>O</i>-methyltransferase from Perilla Leaves and Its Application in 7-Methoxyflavonoid Production
by: Hye Lin Park, et al.
Published: (2020-09-01)

Catalyst-Solvent System for PASE Approach to Hydroxyquinolinone-Substituted Chromeno[2,3-<i>b</i>]pyridines Its Quantum Chemical Study and Investigation of Reaction Mechanism
by: Fedor V. Ryzhkov, et al.
Published: (2020-05-01)

<i>CHI3L1</i>, <i>NTRK2</i>, <i>1p/19q</i> and <i>IDH</i> Status Predicts Prognosis in Glioma
by: Elise Deluche, et al.
Published: (2019-04-01)

<i>Chlamydomonas reinhardtii</i> Is a Potential Food Supplement with the Capacity to Outperform <i>Chlorella</i> and <i>Spirulina</i>
by: Randa Darwish, et al.
Published: (2020-09-01)

Trafficking and Association of <i>Plasmodium falciparum</i> MC-2TM with the Maurer’s Clefts
by: Raghavendra Yadavalli, et al.
Published: (2021-04-01)

A Novel Series of [1,2,4]Triazolo[4,3-a]Pyridine Sulfonamides as Potential Antimalarial Agents: In Silico Studies, Synthesis and In Vitro Evaluation
by: Veronika R. Karpina, et al.
Published: (2020-09-01)