Butea monosperma Reduces Haloperidol and Sulpiride Induced Hyperprolactinemia in Rats

• Main Authors: Prashant Tiwari, Sunil Kumar Dubey, Pratap Kumar Sahu
• Format: Article
• Language: English
• Published: Krishna Institute of Medical Sciences University 2019-04-01
• Series: Journal of Krishna Institute of Medical Sciences University
• Subjects: Haloperidol; sulpiride; prolactin; dopamine; catalase; superoxide dismutase
• Online Access: https://www.jkimsu.com/jkimsu-vol8no2/JKIMSU,%20Vol.%208,%20No.%202,%20April-June%202019%20Page%2040-52.pdf

Background: Prolonged administration of neuroleptic drugs cause disrupted D dopamine receptor which leads to increased prolactin level, causes gyanaecomastia. Presently, dopamine receptor agonist is the choice of treatment for hyperprolactinemia. Aim and Objectives: The study aims to determine the antihyperprolactinemic effect of methanolic extract of Butea monosperma (MEBM) against haloperidol (HPL) and sulpiride (SPD) induced hyperprolactinemia and to correlate with its active constituents. Material and Methods: To induce hyperprolactinemia HPL 5 mg/kg for 16 continuous days and SPD 20 mg/kg for 28 continuous days was administred. MEBM 200 mg/kg/day and 400 mg/kg/day were administered for 16 and 28 days respectively half an hour before administration of HPL and SPD. The serum prolactin (PRL) level, dopamine (DA) level and antioxidant status in the rat brain, hematological parameters were measured and histological examination of the anterior pituitary gland, adrenal gland and spleen were done. In addition, antioxidant enzymes like superoxide dismutase (SOD) and catalase (CAT) were also estimated. Results: MEBM decreases serum PRL level and increased DA level in brain significantly. Further, MEBM also restored SOD and CAT status significantly. The inflammatory markers induced by HPL and SPD were suppressed by MEBM. Discussion: Neuronal DA inhibition by neuroleptic drugs decreases the release of DA which leads to hyperprolactinemia. MEBM (butrin) may activate DA neurones to ameliorate hyperprolactinaemia. The dopaminergic, anti-oxidant and anti-inflammatory effect of MEBM may be attributed to its anti-hyperprolactinemic effect. Conclusion: Butea monosperma possesses anti-hyperprolactinemic effect which may be attributed to its marker constituent like Butrin.