Role of Biofilms in Children with Chronic Adenoiditis and Middle Ear Disease

Chronic adenoiditis occurs frequently in children, and it is complicated by the subsequent development of recurrent or chronic middle ear diseases, such as recurrent acute otitis media, persistent otitis media with effusion and chronic otitis media, which may predispose a child to long-term function...

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Main Authors: Sara Torretta, Lorenzo Drago, Paola Marchisio, Tullio Ibba, Lorenzo Pignataro
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Journal of Clinical Medicine
Subjects:
Online Access:https://www.mdpi.com/2077-0383/8/5/671
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spelling doaj-db9eb59d76bb46c0b730e8c356e375522020-11-24T21:32:33ZengMDPI AGJournal of Clinical Medicine2077-03832019-05-018567110.3390/jcm8050671jcm8050671Role of Biofilms in Children with Chronic Adenoiditis and Middle Ear DiseaseSara Torretta0Lorenzo Drago1Paola Marchisio2Tullio Ibba3Lorenzo Pignataro4Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Policlinico of Milan, Via Francesco Sforza, 35, 20122 Milano, ItalyClinical Chemistry and Microbiology Laboratory, IRCCS Galeazzi Institute and LITA Clinical Microbiology Laboratory, 20161 Milano, ItalyFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Policlinico of Milan, Via Francesco Sforza, 35, 20122 Milano, ItalyFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Policlinico of Milan, Via Francesco Sforza, 35, 20122 Milano, ItalyFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Policlinico of Milan, Via Francesco Sforza, 35, 20122 Milano, ItalyChronic adenoiditis occurs frequently in children, and it is complicated by the subsequent development of recurrent or chronic middle ear diseases, such as recurrent acute otitis media, persistent otitis media with effusion and chronic otitis media, which may predispose a child to long-term functional sequalae and auditory impairment. Children with chronic adenoidal disease who fail to respond to traditional antibiotic therapy are usually candidates for surgery under general anaesthesia. It has been suggested that the ineffectiveness of antibiotic therapy in children with chronic adenoiditis is partially related to nasopharyngeal bacterial biofilms, which play a role in the development of chronic nasopharyngeal inflammation due to chronic adenoiditis, which is possibly associated with chronic or recurrent middle ear disease. This paper reviews the current evidence concerning the involvement of bacterial biofilms in the development of chronic adenoiditis and related middle ear infections in children.https://www.mdpi.com/2077-0383/8/5/671Biofilmadenoidsnasopharynxupper respiratory tract infectionsotitis
collection DOAJ
language English
format Article
sources DOAJ
author Sara Torretta
Lorenzo Drago
Paola Marchisio
Tullio Ibba
Lorenzo Pignataro
spellingShingle Sara Torretta
Lorenzo Drago
Paola Marchisio
Tullio Ibba
Lorenzo Pignataro
Role of Biofilms in Children with Chronic Adenoiditis and Middle Ear Disease
Journal of Clinical Medicine
Biofilm
adenoids
nasopharynx
upper respiratory tract infections
otitis
author_facet Sara Torretta
Lorenzo Drago
Paola Marchisio
Tullio Ibba
Lorenzo Pignataro
author_sort Sara Torretta
title Role of Biofilms in Children with Chronic Adenoiditis and Middle Ear Disease
title_short Role of Biofilms in Children with Chronic Adenoiditis and Middle Ear Disease
title_full Role of Biofilms in Children with Chronic Adenoiditis and Middle Ear Disease
title_fullStr Role of Biofilms in Children with Chronic Adenoiditis and Middle Ear Disease
title_full_unstemmed Role of Biofilms in Children with Chronic Adenoiditis and Middle Ear Disease
title_sort role of biofilms in children with chronic adenoiditis and middle ear disease
publisher MDPI AG
series Journal of Clinical Medicine
issn 2077-0383
publishDate 2019-05-01
description Chronic adenoiditis occurs frequently in children, and it is complicated by the subsequent development of recurrent or chronic middle ear diseases, such as recurrent acute otitis media, persistent otitis media with effusion and chronic otitis media, which may predispose a child to long-term functional sequalae and auditory impairment. Children with chronic adenoidal disease who fail to respond to traditional antibiotic therapy are usually candidates for surgery under general anaesthesia. It has been suggested that the ineffectiveness of antibiotic therapy in children with chronic adenoiditis is partially related to nasopharyngeal bacterial biofilms, which play a role in the development of chronic nasopharyngeal inflammation due to chronic adenoiditis, which is possibly associated with chronic or recurrent middle ear disease. This paper reviews the current evidence concerning the involvement of bacterial biofilms in the development of chronic adenoiditis and related middle ear infections in children.
topic Biofilm
adenoids
nasopharynx
upper respiratory tract infections
otitis
url https://www.mdpi.com/2077-0383/8/5/671
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