Role of Biofilms in Children with Chronic Adenoiditis and Middle Ear Disease
Chronic adenoiditis occurs frequently in children, and it is complicated by the subsequent development of recurrent or chronic middle ear diseases, such as recurrent acute otitis media, persistent otitis media with effusion and chronic otitis media, which may predispose a child to long-term function...
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doaj-db9eb59d76bb46c0b730e8c356e375522020-11-24T21:32:33ZengMDPI AGJournal of Clinical Medicine2077-03832019-05-018567110.3390/jcm8050671jcm8050671Role of Biofilms in Children with Chronic Adenoiditis and Middle Ear DiseaseSara Torretta0Lorenzo Drago1Paola Marchisio2Tullio Ibba3Lorenzo Pignataro4Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Policlinico of Milan, Via Francesco Sforza, 35, 20122 Milano, ItalyClinical Chemistry and Microbiology Laboratory, IRCCS Galeazzi Institute and LITA Clinical Microbiology Laboratory, 20161 Milano, ItalyFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Policlinico of Milan, Via Francesco Sforza, 35, 20122 Milano, ItalyFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Policlinico of Milan, Via Francesco Sforza, 35, 20122 Milano, ItalyFondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Policlinico of Milan, Via Francesco Sforza, 35, 20122 Milano, ItalyChronic adenoiditis occurs frequently in children, and it is complicated by the subsequent development of recurrent or chronic middle ear diseases, such as recurrent acute otitis media, persistent otitis media with effusion and chronic otitis media, which may predispose a child to long-term functional sequalae and auditory impairment. Children with chronic adenoidal disease who fail to respond to traditional antibiotic therapy are usually candidates for surgery under general anaesthesia. It has been suggested that the ineffectiveness of antibiotic therapy in children with chronic adenoiditis is partially related to nasopharyngeal bacterial biofilms, which play a role in the development of chronic nasopharyngeal inflammation due to chronic adenoiditis, which is possibly associated with chronic or recurrent middle ear disease. This paper reviews the current evidence concerning the involvement of bacterial biofilms in the development of chronic adenoiditis and related middle ear infections in children.https://www.mdpi.com/2077-0383/8/5/671Biofilmadenoidsnasopharynxupper respiratory tract infectionsotitis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sara Torretta Lorenzo Drago Paola Marchisio Tullio Ibba Lorenzo Pignataro |
spellingShingle |
Sara Torretta Lorenzo Drago Paola Marchisio Tullio Ibba Lorenzo Pignataro Role of Biofilms in Children with Chronic Adenoiditis and Middle Ear Disease Journal of Clinical Medicine Biofilm adenoids nasopharynx upper respiratory tract infections otitis |
author_facet |
Sara Torretta Lorenzo Drago Paola Marchisio Tullio Ibba Lorenzo Pignataro |
author_sort |
Sara Torretta |
title |
Role of Biofilms in Children with Chronic Adenoiditis and Middle Ear Disease |
title_short |
Role of Biofilms in Children with Chronic Adenoiditis and Middle Ear Disease |
title_full |
Role of Biofilms in Children with Chronic Adenoiditis and Middle Ear Disease |
title_fullStr |
Role of Biofilms in Children with Chronic Adenoiditis and Middle Ear Disease |
title_full_unstemmed |
Role of Biofilms in Children with Chronic Adenoiditis and Middle Ear Disease |
title_sort |
role of biofilms in children with chronic adenoiditis and middle ear disease |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2019-05-01 |
description |
Chronic adenoiditis occurs frequently in children, and it is complicated by the subsequent development of recurrent or chronic middle ear diseases, such as recurrent acute otitis media, persistent otitis media with effusion and chronic otitis media, which may predispose a child to long-term functional sequalae and auditory impairment. Children with chronic adenoidal disease who fail to respond to traditional antibiotic therapy are usually candidates for surgery under general anaesthesia. It has been suggested that the ineffectiveness of antibiotic therapy in children with chronic adenoiditis is partially related to nasopharyngeal bacterial biofilms, which play a role in the development of chronic nasopharyngeal inflammation due to chronic adenoiditis, which is possibly associated with chronic or recurrent middle ear disease. This paper reviews the current evidence concerning the involvement of bacterial biofilms in the development of chronic adenoiditis and related middle ear infections in children. |
topic |
Biofilm adenoids nasopharynx upper respiratory tract infections otitis |
url |
https://www.mdpi.com/2077-0383/8/5/671 |
work_keys_str_mv |
AT saratorretta roleofbiofilmsinchildrenwithchronicadenoiditisandmiddleeardisease AT lorenzodrago roleofbiofilmsinchildrenwithchronicadenoiditisandmiddleeardisease AT paolamarchisio roleofbiofilmsinchildrenwithchronicadenoiditisandmiddleeardisease AT tullioibba roleofbiofilmsinchildrenwithchronicadenoiditisandmiddleeardisease AT lorenzopignataro roleofbiofilmsinchildrenwithchronicadenoiditisandmiddleeardisease |
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