Lobular architecture of human adipose tissue defines the niche and fate of progenitor cells

Lobular architecture of human adipose tissue defines the niche and fate of progenitor cells

In human adipose tissue (AT), adipocytes are organized into units of lobules. Here the authors identify distinct fibrous septal and stromal compartments within AT lobules that differ in composition and potential between subcutaneous and visceral regions and are disturbed in obesity and metabolic syn...

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Main Authors: D. Estève, N. Boulet, C. Belles, A. Zakaroff-Girard, P. Decaunes, A. Briot, Y. Veeranagouda, M. Didier, A. Remaury, J. C. Guillemot, S. Ledoux, C. Dani, A. Bouloumié, J. Galitzky
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09992-3
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spelling doaj-dba09988bc1e42c79fc9d479582cd0492021-05-11T12:20:56ZengNature Publishing GroupNature Communications2041-17232019-06-0110111610.1038/s41467-019-09992-3Lobular architecture of human adipose tissue defines the niche and fate of progenitor cellsD. Estève0N. Boulet1C. Belles2A. Zakaroff-Girard3P. Decaunes4A. Briot5Y. Veeranagouda6M. Didier7A. Remaury8J. C. Guillemot9S. Ledoux10C. Dani11A. Bouloumié12J. Galitzky13Inserm, UMR 1048, Team 1, I2MC, Institute of Metabolic and Cardiovascular Diseases, Université de Toulouse, BP84225Inserm, UMR 1048, Team 1, I2MC, Institute of Metabolic and Cardiovascular Diseases, Université de Toulouse, BP84225Inserm, UMR 1048, Team 1, I2MC, Institute of Metabolic and Cardiovascular Diseases, Université de Toulouse, BP84225Inserm, UMR 1048, Team 1, I2MC, Institute of Metabolic and Cardiovascular Diseases, Université de Toulouse, BP84225Inserm, UMR 1048, Team 1, I2MC, Institute of Metabolic and Cardiovascular Diseases, Université de Toulouse, BP84225Inserm, UMR 1048, Team 1, I2MC, Institute of Metabolic and Cardiovascular Diseases, Université de Toulouse, BP84225Sanofi Aventis Research & Development, Translational SciencesSanofi Aventis Research & Development, Translational SciencesSanofi Aventis Research & Development, Translational SciencesSanofi Aventis Research & Development, Translational SciencesCenter Support of Obesity, Louis Mourier Hospital, Université Paris DiderotUniversité Côte-d’Azur, Inserm, CNRS iBVInserm, UMR 1048, Team 1, I2MC, Institute of Metabolic and Cardiovascular Diseases, Université de Toulouse, BP84225Inserm, UMR 1048, Team 1, I2MC, Institute of Metabolic and Cardiovascular Diseases, Université de Toulouse, BP84225In human adipose tissue (AT), adipocytes are organized into units of lobules. Here the authors identify distinct fibrous septal and stromal compartments within AT lobules that differ in composition and potential between subcutaneous and visceral regions and are disturbed in obesity and metabolic syndrome.https://doi.org/10.1038/s41467-019-09992-3
collection DOAJ
language English
format Article
sources DOAJ
author D. Estève
N. Boulet
C. Belles
A. Zakaroff-Girard
P. Decaunes
A. Briot
Y. Veeranagouda
M. Didier
A. Remaury
J. C. Guillemot
S. Ledoux
C. Dani
A. Bouloumié
J. Galitzky
spellingShingle D. Estève
N. Boulet
C. Belles
A. Zakaroff-Girard
P. Decaunes
A. Briot
Y. Veeranagouda
M. Didier
A. Remaury
J. C. Guillemot
S. Ledoux
C. Dani
A. Bouloumié
J. Galitzky
Lobular architecture of human adipose tissue defines the niche and fate of progenitor cells
Nature Communications
author_facet D. Estève
N. Boulet
C. Belles
A. Zakaroff-Girard
P. Decaunes
A. Briot
Y. Veeranagouda
M. Didier
A. Remaury
J. C. Guillemot
S. Ledoux
C. Dani
A. Bouloumié
J. Galitzky
author_sort D. Estève
title Lobular architecture of human adipose tissue defines the niche and fate of progenitor cells
title_short Lobular architecture of human adipose tissue defines the niche and fate of progenitor cells
title_full Lobular architecture of human adipose tissue defines the niche and fate of progenitor cells
title_fullStr Lobular architecture of human adipose tissue defines the niche and fate of progenitor cells
title_full_unstemmed Lobular architecture of human adipose tissue defines the niche and fate of progenitor cells
title_sort lobular architecture of human adipose tissue defines the niche and fate of progenitor cells
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-06-01
description In human adipose tissue (AT), adipocytes are organized into units of lobules. Here the authors identify distinct fibrous septal and stromal compartments within AT lobules that differ in composition and potential between subcutaneous and visceral regions and are disturbed in obesity and metabolic syndrome.
url https://doi.org/10.1038/s41467-019-09992-3
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