Linking Peroxiredoxin and Vacuolar-ATPase Functions in Calorie Restriction-Mediated Life Span Extension
Calorie restriction (CR) is an intervention extending the life spans of many organisms. The mechanisms underlying CR-dependent retardation of aging are still poorly understood. Despite mechanisms involving conserved nutrient signaling pathways proposed, few target processes that can account for CR-m...
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doaj-dba191fea2874d6795805d4c76b32b762020-11-24T21:11:43ZengHindawi LimitedInternational Journal of Cell Biology1687-88761687-88842014-01-01201410.1155/2014/913071913071Linking Peroxiredoxin and Vacuolar-ATPase Functions in Calorie Restriction-Mediated Life Span ExtensionMikael Molin0Ayse Banu Demir1Department of Chemistry and Molecular Biology, University of Gothenburg, Medicinaregatan 9C, 413 90 Gothenburg, SwedenDepartment of Chemistry and Molecular Biology, University of Gothenburg, Medicinaregatan 9C, 413 90 Gothenburg, SwedenCalorie restriction (CR) is an intervention extending the life spans of many organisms. The mechanisms underlying CR-dependent retardation of aging are still poorly understood. Despite mechanisms involving conserved nutrient signaling pathways proposed, few target processes that can account for CR-mediated longevity have so far been identified. Recently, both peroxiredoxins and vacuolar-ATPases were reported to control CR-mediated retardation of aging downstream of conserved nutrient signaling pathways. In this review, we focus on peroxiredoxin-mediated stress-defence and vacuolar-ATPase regulated acidification and pinpoint common denominators between the two mechanisms proposed for how CR extends life span. Both the activities of peroxiredoxins and vacuolar-ATPases are stimulated upon CR through reduced activities in conserved nutrient signaling pathways and both seem to stimulate cellular resistance to peroxide-stress. However, whereas vacuolar-ATPases have recently been suggested to control both Ras-cAMP-PKA- and TORC1-mediated nutrient signaling, neither the physiological benefits of a proposed role for peroxiredoxins in H2O2-signaling nor downstream targets regulated are known. Both peroxiredoxins and vacuolar-ATPases do, however, impinge on mitochondrial iron-metabolism and further characterization of their impact on iron homeostasis and peroxide-resistance might therefore increase our understanding of the beneficial effects of CR on aging and age-related diseases.http://dx.doi.org/10.1155/2014/913071 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mikael Molin Ayse Banu Demir |
spellingShingle |
Mikael Molin Ayse Banu Demir Linking Peroxiredoxin and Vacuolar-ATPase Functions in Calorie Restriction-Mediated Life Span Extension International Journal of Cell Biology |
author_facet |
Mikael Molin Ayse Banu Demir |
author_sort |
Mikael Molin |
title |
Linking Peroxiredoxin and Vacuolar-ATPase Functions in Calorie Restriction-Mediated Life Span Extension |
title_short |
Linking Peroxiredoxin and Vacuolar-ATPase Functions in Calorie Restriction-Mediated Life Span Extension |
title_full |
Linking Peroxiredoxin and Vacuolar-ATPase Functions in Calorie Restriction-Mediated Life Span Extension |
title_fullStr |
Linking Peroxiredoxin and Vacuolar-ATPase Functions in Calorie Restriction-Mediated Life Span Extension |
title_full_unstemmed |
Linking Peroxiredoxin and Vacuolar-ATPase Functions in Calorie Restriction-Mediated Life Span Extension |
title_sort |
linking peroxiredoxin and vacuolar-atpase functions in calorie restriction-mediated life span extension |
publisher |
Hindawi Limited |
series |
International Journal of Cell Biology |
issn |
1687-8876 1687-8884 |
publishDate |
2014-01-01 |
description |
Calorie restriction (CR) is an intervention extending the life spans of many organisms. The mechanisms underlying CR-dependent retardation of aging are still poorly understood. Despite mechanisms involving conserved nutrient signaling pathways proposed, few target processes that can account for CR-mediated longevity have so far been identified. Recently, both peroxiredoxins and vacuolar-ATPases were reported to control CR-mediated retardation of aging downstream of conserved nutrient signaling pathways. In this review, we focus on peroxiredoxin-mediated stress-defence and vacuolar-ATPase regulated acidification and pinpoint common denominators between the two mechanisms proposed for how CR extends life span. Both the activities of peroxiredoxins and vacuolar-ATPases are stimulated upon CR through reduced activities in conserved nutrient signaling pathways and both seem to stimulate cellular resistance to peroxide-stress. However, whereas vacuolar-ATPases have recently been suggested to control both Ras-cAMP-PKA- and TORC1-mediated nutrient signaling, neither the physiological benefits of a proposed role for peroxiredoxins in H2O2-signaling nor downstream targets regulated are known. Both peroxiredoxins and vacuolar-ATPases do, however, impinge on mitochondrial iron-metabolism and further characterization of their impact on iron homeostasis and peroxide-resistance might therefore increase our understanding of the beneficial effects of CR on aging and age-related diseases. |
url |
http://dx.doi.org/10.1155/2014/913071 |
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AT mikaelmolin linkingperoxiredoxinandvacuolaratpasefunctionsincalorierestrictionmediatedlifespanextension AT aysebanudemir linkingperoxiredoxinandvacuolaratpasefunctionsincalorierestrictionmediatedlifespanextension |
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