The Role of Structural Extracellular Matrix Proteins in Urothelial Bladder Cancer (Review)

The Role of Structural Extracellular Matrix Proteins in Urothelial Bladder Cancer (Review)

The extracellular matrix (ECM) plays a key role in the modulation of cancer cell invasion. In urothelial carcinoma of the bladder (UC) the role of ECM proteins has been widely studied. The mechanisms, which are involved in the development of invasion, progression and generalization, are complex, dep...

Full description

Bibliographic Details
Main Authors: Andrea Brunner, Alexandar Tzankov
Format: Article
Language:English
Published: SAGE Publishing 2007-01-01
Series:Biomarker Insights
Online Access:https://doi.org/10.4137/BMI.S294
id doaj-dba43afef6b84f11bb987deace419487
record_format Article
spelling doaj-dba43afef6b84f11bb987deace4194872020-11-25T03:24:07ZengSAGE PublishingBiomarker Insights1177-27192007-01-01210.4137/BMI.S294The Role of Structural Extracellular Matrix Proteins in Urothelial Bladder Cancer (Review)Andrea Brunner0Alexandar Tzankov1Institute of Pathology, Medical University of Innsbruck, Innsbruck, Austria.Institute of Pathology, University of Basel, Basel, Switzerland.The extracellular matrix (ECM) plays a key role in the modulation of cancer cell invasion. In urothelial carcinoma of the bladder (UC) the role of ECM proteins has been widely studied. The mechanisms, which are involved in the development of invasion, progression and generalization, are complex, depending on the interaction of ECM proteins with each other as well as with cancer cells. The following review will focus on the pathogenetic role and prognostic value of structural proteins, such as laminins, collagens, fibronectin (FN), tenascin (Tn-C) and thrombospondin 1 (TSP1) in UC. In addition the role of integrins mediating the interaction of ECM molecules and cancer cells will be addressed, since integrin-mediated FN, Tn-C and TSP1 interactions seem to play an important role during tumor cell invasion and angiogenesis.https://doi.org/10.4137/BMI.S294
collection DOAJ
language English
format Article
sources DOAJ
author Andrea Brunner
Alexandar Tzankov
spellingShingle Andrea Brunner
Alexandar Tzankov
The Role of Structural Extracellular Matrix Proteins in Urothelial Bladder Cancer (Review)
Biomarker Insights
author_facet Andrea Brunner
Alexandar Tzankov
author_sort Andrea Brunner
title The Role of Structural Extracellular Matrix Proteins in Urothelial Bladder Cancer (Review)
title_short The Role of Structural Extracellular Matrix Proteins in Urothelial Bladder Cancer (Review)
title_full The Role of Structural Extracellular Matrix Proteins in Urothelial Bladder Cancer (Review)
title_fullStr The Role of Structural Extracellular Matrix Proteins in Urothelial Bladder Cancer (Review)
title_full_unstemmed The Role of Structural Extracellular Matrix Proteins in Urothelial Bladder Cancer (Review)
title_sort role of structural extracellular matrix proteins in urothelial bladder cancer (review)
publisher SAGE Publishing
series Biomarker Insights
issn 1177-2719
publishDate 2007-01-01
description The extracellular matrix (ECM) plays a key role in the modulation of cancer cell invasion. In urothelial carcinoma of the bladder (UC) the role of ECM proteins has been widely studied. The mechanisms, which are involved in the development of invasion, progression and generalization, are complex, depending on the interaction of ECM proteins with each other as well as with cancer cells. The following review will focus on the pathogenetic role and prognostic value of structural proteins, such as laminins, collagens, fibronectin (FN), tenascin (Tn-C) and thrombospondin 1 (TSP1) in UC. In addition the role of integrins mediating the interaction of ECM molecules and cancer cells will be addressed, since integrin-mediated FN, Tn-C and TSP1 interactions seem to play an important role during tumor cell invasion and angiogenesis.
url https://doi.org/10.4137/BMI.S294
work_keys_str_mv AT andreabrunner theroleofstructuralextracellularmatrixproteinsinurothelialbladdercancerreview
AT alexandartzankov theroleofstructuralextracellularmatrixproteinsinurothelialbladdercancerreview
AT andreabrunner roleofstructuralextracellularmatrixproteinsinurothelialbladdercancerreview
AT alexandartzankov roleofstructuralextracellularmatrixproteinsinurothelialbladdercancerreview
_version_ 1724603263644336128

Similar Items