The Gene-Lifestyle Interaction on Leptin Sensitivity and Lipid Metabolism in Adults: A Population Based Study
Background: Obesity has been associated with leptin resistance and this might be caused by genetic factors. The aim of this study was to investigate the gene-lifestyle interaction between −866G/A UCP2 (uncoupling protein 2) gene polymorphism, dietary intake and leptin in a population based study. Me...
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doaj-dba5d865dbe64e4fb68f0e3c9ef616232020-11-24T22:20:12ZengMDPI AGNutrients2072-66432017-07-019771610.3390/nu9070716nu9070716The Gene-Lifestyle Interaction on Leptin Sensitivity and Lipid Metabolism in Adults: A Population Based StudyHarry Freitag Luglio0Dian Caturini Sulistyoningrum1Emy Huriyati2Yi Yi Lee3Wan Abdul Manan Wan Muda4Department of Nutrition and Health, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta 55281, IndonesiaDepartment of Nutrition and Health, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta 55281, IndonesiaDepartment of Nutrition and Health, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta 55281, IndonesiaSchool of Health Sciences, Universiti Sains Malaysia, Gelugor 11800, MalaysiaCenter for Southeast Asian Studies, Kyoto University, Kyoto 606-8501, JapanBackground: Obesity has been associated with leptin resistance and this might be caused by genetic factors. The aim of this study was to investigate the gene-lifestyle interaction between −866G/A UCP2 (uncoupling protein 2) gene polymorphism, dietary intake and leptin in a population based study. Methods: This is a cross sectional study conducted in adults living at urban area of Yogyakarta, Indonesia. Data of adiposity, lifestyle, triglyceride, high density lipoprotein (HDL) cholesterol, leptin and UCP2 gene polymorphism were obtained in 380 men and female adults. Results: UCP2 gene polymorphism was not significantly associated with adiposity, leptin, triglyceride, HDL cholesterol, dietary intake and physical activity (all p > 0.05). Leptin was lower in overweight subjects with AA + GA genotypes than those with GG genotype counterparts (p = 0.029). In subjects with AA + GA genotypes there was a negative correlation between leptin concentration (r = −0.324; p < 0.0001) and total energy intake and this correlation was not seen in GG genotype (r = −0.111; p = 0.188). Conclusions: In summary, we showed how genetic variation in −866G/A UCP2 affected individual response to leptin production. AA + GA genotype had a better leptin sensitivity shown by its response in dietary intake and body mass index (BMI) and this explained the protective effect of A allele to obesity.https://www.mdpi.com/2072-6643/9/7/716UCP2leptindietary intakeadiposityobesity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Harry Freitag Luglio Dian Caturini Sulistyoningrum Emy Huriyati Yi Yi Lee Wan Abdul Manan Wan Muda |
spellingShingle |
Harry Freitag Luglio Dian Caturini Sulistyoningrum Emy Huriyati Yi Yi Lee Wan Abdul Manan Wan Muda The Gene-Lifestyle Interaction on Leptin Sensitivity and Lipid Metabolism in Adults: A Population Based Study Nutrients UCP2 leptin dietary intake adiposity obesity |
author_facet |
Harry Freitag Luglio Dian Caturini Sulistyoningrum Emy Huriyati Yi Yi Lee Wan Abdul Manan Wan Muda |
author_sort |
Harry Freitag Luglio |
title |
The Gene-Lifestyle Interaction on Leptin Sensitivity and Lipid Metabolism in Adults: A Population Based Study |
title_short |
The Gene-Lifestyle Interaction on Leptin Sensitivity and Lipid Metabolism in Adults: A Population Based Study |
title_full |
The Gene-Lifestyle Interaction on Leptin Sensitivity and Lipid Metabolism in Adults: A Population Based Study |
title_fullStr |
The Gene-Lifestyle Interaction on Leptin Sensitivity and Lipid Metabolism in Adults: A Population Based Study |
title_full_unstemmed |
The Gene-Lifestyle Interaction on Leptin Sensitivity and Lipid Metabolism in Adults: A Population Based Study |
title_sort |
gene-lifestyle interaction on leptin sensitivity and lipid metabolism in adults: a population based study |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2017-07-01 |
description |
Background: Obesity has been associated with leptin resistance and this might be caused by genetic factors. The aim of this study was to investigate the gene-lifestyle interaction between −866G/A UCP2 (uncoupling protein 2) gene polymorphism, dietary intake and leptin in a population based study. Methods: This is a cross sectional study conducted in adults living at urban area of Yogyakarta, Indonesia. Data of adiposity, lifestyle, triglyceride, high density lipoprotein (HDL) cholesterol, leptin and UCP2 gene polymorphism were obtained in 380 men and female adults. Results: UCP2 gene polymorphism was not significantly associated with adiposity, leptin, triglyceride, HDL cholesterol, dietary intake and physical activity (all p > 0.05). Leptin was lower in overweight subjects with AA + GA genotypes than those with GG genotype counterparts (p = 0.029). In subjects with AA + GA genotypes there was a negative correlation between leptin concentration (r = −0.324; p < 0.0001) and total energy intake and this correlation was not seen in GG genotype (r = −0.111; p = 0.188). Conclusions: In summary, we showed how genetic variation in −866G/A UCP2 affected individual response to leptin production. AA + GA genotype had a better leptin sensitivity shown by its response in dietary intake and body mass index (BMI) and this explained the protective effect of A allele to obesity. |
topic |
UCP2 leptin dietary intake adiposity obesity |
url |
https://www.mdpi.com/2072-6643/9/7/716 |
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