Maternal outcomes and risk factors for COVID-19 severity among pregnant women
Abstract Pregnant women may be at higher risk of severe complications associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical complications. We performed a case control study comparing pregnant women with severe coronavirus disease 19 (cases) t...
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Format: | Article |
Language: | English |
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Nature Publishing Group
2021-07-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-021-92357-y |
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Manon Vouga Guillaume Favre Oscar Martinez-Perez Leo Pomar Laura Forcen Acebal Alejandra Abascal-Saiz Maria Rosa Vila Hernandez Najeh Hcini Véronique Lambert Gabriel Carles Joanna Sichitiu Laurent Salomon Julien Stirnemann Yves Ville Begoña Martinez de Tejada Anna Goncé Ameth Hawkins-Villarreal Karen Castillo Eduard Gratacos Solsona Lucas Trigo Brian Cleary Michael Geary Helena Bartels Feras Al-Kharouf Fergal Malone Mary Higgins Niamh Keating Susan Knowles Christophe Poncelet Carolina Carvalho Ribeiro-do-Valle Fernanda Surita Amanda Dantas-Silva Carolina Borrelli Adriana Gomes Luz Javiera Fuenzalida Jorge Carvajal Manuel Guerra Canales Olivia Hernandez Olga Grechukhina Albert I. Ko Uma Reddy Rita Figueiredo Marina Moucho Pedro Viana Pinto Carmen De Luca Marco De Santis Diogo Ayres de Campos Inês Martins Charles Garabedian Damien Subtil Betania Bohrer Maria Lucia Da Rocha Oppermann Maria Celeste Osorio Wender Lavinia Schuler-Faccini Maria Teresa Vieira Sanseverino Camila Giugliani Luciana Friedrich Mariana Horn Scherer Nicolas Mottet Guillaume Ducarme Helene Pelerin Chloe Moreau Bénédicte Breton Thibaud Quibel Patrick Rozenberg Eric Giannoni Cristina Granado Cécile Monod Doris Mueller Irene Hoesli Dirk Bassler Sandra Heldstab Nicole Ochsenbein Kölble Loïc Sentilhes Melissa Charvet Jan Deprest Jute Richter Lennart Van der Veeken Béatrice Eggel-Hort Gaetan Plantefeve Mohamed Derouich Albaro José Nieto Calvache Maria Camila Lopez-Giron Juan Manuel Burgos-Luna Maria Fernanda Escobar-Vidarte Kurt Hecher Ann-Christin Tallarek Eran Hadar Karina Krajden Haratz Uri Amikam Gustavo Malinger Ron Maymon Yariv Yogev Leonhard Schäffer Arnaud Toussaint Marie-Claude Rossier Renato Augusto Moreira De Sa Claudia Grawe Karoline Aebi-Popp Anda-Petronela Radan Luigi Raio Daniel Surbek Paul Böckenhoff Brigitte Strizek Martin Kaufmann Andrea Bloch Michel Boulvain Silke Johann Sandra Andrea Heldstab Monya Todesco Bernasconi Gaston Grant Anis Feki Anne-Claude Muller Brochut Marylene Giral Lucie Sedille Andrea Papadia Romina Capoccia Brugger Brigitte Weber Tina Fischer Christian Kahlert Karin Nielsen Saines Mary Cambou Panagiotis Kanellos Xiang Chen Mingzhu Yin Annina Haessig Sandrine Ackermann David Baud Alice Panchaud |
spellingShingle |
Manon Vouga Guillaume Favre Oscar Martinez-Perez Leo Pomar Laura Forcen Acebal Alejandra Abascal-Saiz Maria Rosa Vila Hernandez Najeh Hcini Véronique Lambert Gabriel Carles Joanna Sichitiu Laurent Salomon Julien Stirnemann Yves Ville Begoña Martinez de Tejada Anna Goncé Ameth Hawkins-Villarreal Karen Castillo Eduard Gratacos Solsona Lucas Trigo Brian Cleary Michael Geary Helena Bartels Feras Al-Kharouf Fergal Malone Mary Higgins Niamh Keating Susan Knowles Christophe Poncelet Carolina Carvalho Ribeiro-do-Valle Fernanda Surita Amanda Dantas-Silva Carolina Borrelli Adriana Gomes Luz Javiera Fuenzalida Jorge Carvajal Manuel Guerra Canales Olivia Hernandez Olga Grechukhina Albert I. Ko Uma Reddy Rita Figueiredo Marina Moucho Pedro Viana Pinto Carmen De Luca Marco De Santis Diogo Ayres de Campos Inês Martins Charles Garabedian Damien Subtil Betania Bohrer Maria Lucia Da Rocha Oppermann Maria Celeste Osorio Wender Lavinia Schuler-Faccini Maria Teresa Vieira Sanseverino Camila Giugliani Luciana Friedrich Mariana Horn Scherer Nicolas Mottet Guillaume Ducarme Helene Pelerin Chloe Moreau Bénédicte Breton Thibaud Quibel Patrick Rozenberg Eric Giannoni Cristina Granado Cécile Monod Doris Mueller Irene Hoesli Dirk Bassler Sandra Heldstab Nicole Ochsenbein Kölble Loïc Sentilhes Melissa Charvet Jan Deprest Jute Richter Lennart Van der Veeken Béatrice Eggel-Hort Gaetan Plantefeve Mohamed Derouich Albaro José Nieto Calvache Maria Camila Lopez-Giron Juan Manuel Burgos-Luna Maria Fernanda Escobar-Vidarte Kurt Hecher Ann-Christin Tallarek Eran Hadar Karina Krajden Haratz Uri Amikam Gustavo Malinger Ron Maymon Yariv Yogev Leonhard Schäffer Arnaud Toussaint Marie-Claude Rossier Renato Augusto Moreira De Sa Claudia Grawe Karoline Aebi-Popp Anda-Petronela Radan Luigi Raio Daniel Surbek Paul Böckenhoff Brigitte Strizek Martin Kaufmann Andrea Bloch Michel Boulvain Silke Johann Sandra Andrea Heldstab Monya Todesco Bernasconi Gaston Grant Anis Feki Anne-Claude Muller Brochut Marylene Giral Lucie Sedille Andrea Papadia Romina Capoccia Brugger Brigitte Weber Tina Fischer Christian Kahlert Karin Nielsen Saines Mary Cambou Panagiotis Kanellos Xiang Chen Mingzhu Yin Annina Haessig Sandrine Ackermann David Baud Alice Panchaud Maternal outcomes and risk factors for COVID-19 severity among pregnant women Scientific Reports |
author_facet |
Manon Vouga Guillaume Favre Oscar Martinez-Perez Leo Pomar Laura Forcen Acebal Alejandra Abascal-Saiz Maria Rosa Vila Hernandez Najeh Hcini Véronique Lambert Gabriel Carles Joanna Sichitiu Laurent Salomon Julien Stirnemann Yves Ville Begoña Martinez de Tejada Anna Goncé Ameth Hawkins-Villarreal Karen Castillo Eduard Gratacos Solsona Lucas Trigo Brian Cleary Michael Geary Helena Bartels Feras Al-Kharouf Fergal Malone Mary Higgins Niamh Keating Susan Knowles Christophe Poncelet Carolina Carvalho Ribeiro-do-Valle Fernanda Surita Amanda Dantas-Silva Carolina Borrelli Adriana Gomes Luz Javiera Fuenzalida Jorge Carvajal Manuel Guerra Canales Olivia Hernandez Olga Grechukhina Albert I. Ko Uma Reddy Rita Figueiredo Marina Moucho Pedro Viana Pinto Carmen De Luca Marco De Santis Diogo Ayres de Campos Inês Martins Charles Garabedian Damien Subtil Betania Bohrer Maria Lucia Da Rocha Oppermann Maria Celeste Osorio Wender Lavinia Schuler-Faccini Maria Teresa Vieira Sanseverino Camila Giugliani Luciana Friedrich Mariana Horn Scherer Nicolas Mottet Guillaume Ducarme Helene Pelerin Chloe Moreau Bénédicte Breton Thibaud Quibel Patrick Rozenberg Eric Giannoni Cristina Granado Cécile Monod Doris Mueller Irene Hoesli Dirk Bassler Sandra Heldstab Nicole Ochsenbein Kölble Loïc Sentilhes Melissa Charvet Jan Deprest Jute Richter Lennart Van der Veeken Béatrice Eggel-Hort Gaetan Plantefeve Mohamed Derouich Albaro José Nieto Calvache Maria Camila Lopez-Giron Juan Manuel Burgos-Luna Maria Fernanda Escobar-Vidarte Kurt Hecher Ann-Christin Tallarek Eran Hadar Karina Krajden Haratz Uri Amikam Gustavo Malinger Ron Maymon Yariv Yogev Leonhard Schäffer Arnaud Toussaint Marie-Claude Rossier Renato Augusto Moreira De Sa Claudia Grawe Karoline Aebi-Popp Anda-Petronela Radan Luigi Raio Daniel Surbek Paul Böckenhoff Brigitte Strizek Martin Kaufmann Andrea Bloch Michel Boulvain Silke Johann Sandra Andrea Heldstab Monya Todesco Bernasconi Gaston Grant Anis Feki Anne-Claude Muller Brochut Marylene Giral Lucie Sedille Andrea Papadia Romina Capoccia Brugger Brigitte Weber Tina Fischer Christian Kahlert Karin Nielsen Saines Mary Cambou Panagiotis Kanellos Xiang Chen Mingzhu Yin Annina Haessig Sandrine Ackermann David Baud Alice Panchaud |
author_sort |
Manon Vouga |
title |
Maternal outcomes and risk factors for COVID-19 severity among pregnant women |
title_short |
Maternal outcomes and risk factors for COVID-19 severity among pregnant women |
title_full |
Maternal outcomes and risk factors for COVID-19 severity among pregnant women |
title_fullStr |
Maternal outcomes and risk factors for COVID-19 severity among pregnant women |
title_full_unstemmed |
Maternal outcomes and risk factors for COVID-19 severity among pregnant women |
title_sort |
maternal outcomes and risk factors for covid-19 severity among pregnant women |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-07-01 |
description |
Abstract Pregnant women may be at higher risk of severe complications associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical complications. We performed a case control study comparing pregnant women with severe coronavirus disease 19 (cases) to pregnant women with a milder form (controls) enrolled in the COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, obstetrical and immediate neonatal outcomes were assessed. A total of 926 pregnant women with a positive test for SARS-CoV-2 were included, among which 92 (9.9%) presented with severe COVID-19 disease. Risk factors for severe maternal outcomes were pulmonary comorbidities [aOR 4.3, 95% CI 1.9–9.5], hypertensive disorders [aOR 2.7, 95% CI 1.0–7.0] and diabetes [aOR2.2, 95% CI 1.1–4.5]. Pregnant women with severe maternal outcomes were at higher risk of caesarean section [70.7% (n = 53/75)], preterm delivery [62.7% (n = 32/51)] and newborns requiring admission to the neonatal intensive care unit [41.3% (n = 31/75)]. In this study, several risk factors for developing severe complications of SARS-CoV-2 infection among pregnant women were identified including pulmonary comorbidities, hypertensive disorders and diabetes. Obstetrical and neonatal outcomes appear to be influenced by the severity of maternal disease. |
url |
https://doi.org/10.1038/s41598-021-92357-y |
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doaj-dba90e7e6bb242b094e0cf5ac1fe59682021-07-11T11:26:45ZengNature Publishing GroupScientific Reports2045-23222021-07-0111111110.1038/s41598-021-92357-yMaternal outcomes and risk factors for COVID-19 severity among pregnant womenManon Vouga0Guillaume Favre1Oscar Martinez-Perez2Leo Pomar3Laura Forcen Acebal4Alejandra Abascal-Saiz5Maria Rosa Vila Hernandez6Najeh Hcini7Véronique Lambert8Gabriel Carles9Joanna Sichitiu10Laurent Salomon11Julien Stirnemann12Yves Ville13Begoña Martinez de Tejada14Anna Goncé15Ameth Hawkins-Villarreal16Karen Castillo17Eduard Gratacos Solsona18Lucas Trigo19Brian Cleary20Michael Geary21Helena Bartels22Feras Al-Kharouf23Fergal Malone24Mary Higgins25Niamh Keating26Susan Knowles27Christophe Poncelet28Carolina Carvalho Ribeiro-do-Valle29Fernanda Surita30Amanda Dantas-Silva31Carolina Borrelli32Adriana Gomes Luz33Javiera Fuenzalida34Jorge Carvajal35Manuel Guerra Canales36Olivia Hernandez37Olga Grechukhina38Albert I. Ko39Uma Reddy40Rita Figueiredo41Marina Moucho42Pedro Viana Pinto43Carmen De Luca44Marco De Santis45Diogo Ayres de Campos46Inês Martins47Charles Garabedian48Damien Subtil49Betania Bohrer50Maria Lucia Da Rocha Oppermann51Maria Celeste Osorio Wender52Lavinia Schuler-Faccini53Maria Teresa Vieira Sanseverino54Camila Giugliani55Luciana Friedrich56Mariana Horn Scherer57Nicolas Mottet58Guillaume Ducarme59Helene Pelerin60Chloe Moreau61Bénédicte Breton62Thibaud Quibel63Patrick Rozenberg64Eric Giannoni65Cristina Granado66Cécile Monod67Doris Mueller68Irene Hoesli69Dirk Bassler70Sandra Heldstab71Nicole Ochsenbein Kölble72Loïc Sentilhes73Melissa Charvet74Jan Deprest75Jute Richter76Lennart Van der Veeken77Béatrice Eggel-Hort78Gaetan Plantefeve79Mohamed Derouich80Albaro José Nieto Calvache81Maria Camila Lopez-Giron82Juan Manuel Burgos-Luna83Maria Fernanda Escobar-Vidarte84Kurt Hecher85Ann-Christin Tallarek86Eran Hadar87Karina Krajden Haratz88Uri Amikam89Gustavo Malinger90Ron Maymon91Yariv Yogev92Leonhard Schäffer93Arnaud Toussaint94Marie-Claude Rossier95Renato Augusto Moreira De Sa96Claudia Grawe97Karoline Aebi-Popp98Anda-Petronela Radan99Luigi Raio100Daniel Surbek101Paul Böckenhoff102Brigitte Strizek103Martin Kaufmann104Andrea Bloch105Michel Boulvain106Silke Johann107Sandra Andrea Heldstab108Monya Todesco Bernasconi109Gaston Grant110Anis Feki111Anne-Claude Muller Brochut112Marylene Giral113Lucie Sedille114Andrea Papadia115Romina Capoccia Brugger116Brigitte Weber117Tina Fischer118Christian Kahlert119Karin Nielsen Saines120Mary Cambou121Panagiotis Kanellos122Xiang Chen123Mingzhu Yin124Annina Haessig125Sandrine Ackermann126David Baud127Alice Panchaud128Materno-fetal and Obstetrics Research Unit, Department “Femme-Mère-Enfant”, University HospitalMaterno-fetal and Obstetrics Research Unit, Department “Femme-Mère-Enfant”, University HospitalObstetricia y Ginecologia, Puerta de Hierro University HospitalMaterno-fetal and Obstetrics Research Unit, Department “Femme-Mère-Enfant”, University HospitalObstetrics and Gynaecology Department, 12 de Octubre University HospitalLa Paz Universitary HospitalHospital Santa CaterinaDepartment of Obstetrics and Gynaecology, CHOGDepartment of Obstetrics and Gynaecology, CHOGDepartment of Obstetrics and Gynaecology, CHOGMaterno-fetal and Obstetrics Research Unit, Department “Femme-Mère-Enfant”, University HospitalObstétrique et de Médecine fœtale, Hopital Necker-Enfants MaladesObstétrique et de Médecine fœtale, Hopital Necker-Enfants MaladesObstétrique et de Médecine fœtale, Hopital Necker-Enfants MaladesObstetrics Division, Department of Pediatrics Gynecology and Obstetrics, University Hospitals of GenevaBCNatal Maternal-Fetal Medicine Service, Hospital Clínic, University of BarcelonaBCNatal Maternal-Fetal Medicine Service, Hospital Clínic, University of BarcelonaBCNatal Maternal-Fetal Medicine Service, Hospital Clínic, University of BarcelonaBCNatal Maternal-Fetal Medicine Service, Hospital Clínic, University of BarcelonaFetal Medicine Research Center, Hospital Clínic and Hospital Sant Joan de DéuService of Pharmacy, The Rotunda HospitalMaternal-fetal Medicine, The Rotunda HospitalMaternal-fetal Medicine, The Rotunda HospitalMaternal-fetal Medicine, The Rotunda HospitalMaternal-fetal Medicine, The Rotunda HospitalUCD Perinatal Research Centre, National Maternity HospitalMaternal Medicine, National Maternity HospitalMicrobiology, National Maternity HospitalObstetric and Gynecology Unit, Centre Hospitalier René DubosDepartment of Obstetrics & Gynecology, University of CampinasDepartment of Obstetrics & Gynecology, University of CampinasDepartment of Obstetrics & Gynecology, University of CampinasDepartment of Obstetrics & Gynecology, University of CampinasDepartment of Obstetrics & Gynecology, University of CampinasMaternal-Fetal Medicine, Department of Obstetrics, Escuela de Medicina, Pontificia Universidad Católica de ChileMaternal-Fetal Medicine, Department of Obstetrics, Escuela de Medicina, Pontificia Universidad Católica de ChileMedicina Materno Fetal, Hospital San JoséHospital Felix Bulnes CerdaDepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale School of MedicineDepartment of Epidemiology of Microbial Diseases, Yale of School of Public HealthDepartment of Epidemiology of Microbial Diseases, Yale of School of Public HealthServiço ginecologia e obstetrícia, Centro Hospitalar e Universitário São JoãoServiço ginecologia e obstetrícia, Centro Hospitalar e Universitário São JoãoServiço ginecologia e obstetrícia, Centro Hospitalar e Universitário São JoãoTeratology Information Service, Fondazione Policlinico Universitario Agostino Gemelli IRCCSTeratology Information Service, Fondazione Policlinico Universitario Agostino Gemelli IRCCSMedical School, Santa Maria University HospitalMedical School, Santa Maria University HospitalDepartment of Obstetrics, Jeanne de Flandre University HospitalDepartment of Obstetrics, Jeanne de Flandre University HospitalPediatra e Neonatologista, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do SulMaternity Ward, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do SulMaternity Ward, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do SulDepartamento de Genética, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do SulDepartamento de Genética, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do SulHospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do SulPediatra e Neonatologista, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do SulDepartamento de Genética, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do SulDepartment of Obstetrics and Gynecology, Université de Franche ComtéDepartment of Obstetrics and Gynecology, Centre Hospitalier Departemental de VendéeClinical Research Department, Centre Hospitalier Départemental de VendéeClinical Research Department, Centre Hospitalier Départemental de VendéeDepartment of Obstetrics and Gynecology, Annecy Genevois HospitalDepartment of Gynecology and Obstetrics, Intercommunal Hospital Centre of Poissy-Saint-Germain-en-LayeDepartment of Gynecology and Obstetrics, Intercommunal Hospital Centre of Poissy-Saint-Germain-en-LayeMaterno-fetal and Obstetrics Research Unit, Department “Femme-Mère-Enfant”, University HospitalDepartment of Obstetrics and Antenatal Care, University Hospital BaselDepartment of Obstetrics and Antenatal Care, University Hospital BaselDepartment of Obstetrics and Antenatal Care, University Hospital BaselDepartment of Obstetrics and Antenatal Care, University Hospital BaselDepartment of Neonatology, UniversitätsSpital ZürichDepartment of Anthropology, University of ZurichClinic of Obstetrics, UniversitätsSpital ZürichDepartment of Obstetrics and Gynecology, Bordeaux University HospitalDepartment of Obstetrics and Gynecology, Bordeaux University HospitalDepartment of Obstetrics and Gynecology, University Hospitals LeuvenDepartment of Obstetrics and Gynecology, University Hospitals LeuvenDepartment of Regeneration and Development, Katholieke Universiteit LeuvenObstetric and Gynecology Unit, Sion HospitalService de Réanimation polyvalente et USC, Victor Dupouy HospitalObstetrics Unit, Victor Dupouy HospitalObstetrics and Gynecology Department, Fundacion Clinica Valle de Lili, Universitary HospitalObstetrics and Gynecology Department, Fundacion Clinica Valle de Lili, Universitary HospitalObstetrics and Gynecology Department, Fundacion Clinica Valle de Lili, Universitary HospitalObstetrics and Gynecology Department, Fundacion Clinica Valle de Lili, Universitary HospitalDepartment of Obstetrics and Fetal Medicine, University Medical Center Hamburg-EppendorfDepartment of Obstetrics and Fetal Medicine, University Medical Center Hamburg-EppendorfMaternal-Fetal Medicine Unit, Rabin Medical Center, Tel-Aviv UniversityDivision of Ultrasound in Obstetrics and Gynecology, Lis Maternity HospitalDivision of Ultrasound in ObGy, Tel Aviv Sourasky Medical CenterDivision of Ultrasound in ObGy, Tel Aviv Sourasky Medical CenterIsraeli Society of Obstetrics and Gynecology, Hasaf Harofe Medical Center, Tel Aviv UniversityDivision of Ultrasound in Obstetrics and Gynecology, Lis Maternity HospitalObstetrics Cantonal Hospital of Baden, Affiliated Hospital of the University of ZurichDepartment of Gynecology and Obstetrics, Intercantonal Hospital of BroyeObstetrics and Gynecology, Hospital Riviera ChablaisMaternal-Fetal Unit, Federal Fluminense UniversityDepartment of Obstetrics, Gynecology Stadtspital Triemli ZürichDepartment of Infectious Diseases, University Hospital BernDepartment of Obstetrics and Gynecology, InselspitalDepartment of Obstetrics and Gynecology, InselspitalDepartment of Obstetrics and Gynecology, InselspitalDepartment of Obstetrics and Prenatal Medicine, University Hospital BonnDepartment of Obstetrics and Prenatal Medicine, University Hospital BonnObstetric and Gynecology Unit, Spital BülachObstetric and Gynecology Unit, Hopital du JuraPôle Department of Gynecology and Obstetrics, GHOL Hôpital de NyonDepartment of Obstetrics and Gynecology Spitalzentrum OBerwallis, Standort VispFrauenklinik, Kantonsspital AarauFrauenklinik, Kantonsspital AarauDepartment of Obstetrics and Gynecology, HFR Fribourg HospitalDepartment of Obstetrics and Gynecology, HFR Fribourg HospitalGynEcho Medical PracticeDepartment of Obstetrics and Gynecology, La Rochelle HospitalDepartment of Obstetrics and Gynecology, La Rochelle HospitalDepartment of Obstetrics and Gynecology, Ente Ospedaliero Cantonale of LuganoDepartment of Obstetrics and Gynecology Réseau Hospitalier NeuchâteloisDepartment of Obstetrics and Gynecology, Kantonsspital Obwalden (KSOW)Frauenklinik, Kantonsspital Saint GallInfectious Diseases and Hospital Epidemiology, Kantonsspital Saint GallDivision of Infectious Diseases, Department of Pediatrics, David Geffen UCLA School of MedicineCardiac Surgery Department, David Geffen UCLA School of MedicineDepartment of Obstetrics and Gynecology, Kantonsspital UriDermatology Unit, Xiangya HospitalHunan Engineering Research Center of Gynecology and Obstetrics Disease, Xiangya HospitalDepartment of Obstetrics and Gynecology, Zuger KantonsspitalMaterno-fetal and Obstetrics Research Unit, Department “Femme-Mère-Enfant”, University HospitalMaterno-fetal and Obstetrics Research Unit, Department “Femme-Mère-Enfant”, University HospitalInstitute of Primary Health Care (BIHAM), University of BernAbstract Pregnant women may be at higher risk of severe complications associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical complications. We performed a case control study comparing pregnant women with severe coronavirus disease 19 (cases) to pregnant women with a milder form (controls) enrolled in the COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, obstetrical and immediate neonatal outcomes were assessed. A total of 926 pregnant women with a positive test for SARS-CoV-2 were included, among which 92 (9.9%) presented with severe COVID-19 disease. Risk factors for severe maternal outcomes were pulmonary comorbidities [aOR 4.3, 95% CI 1.9–9.5], hypertensive disorders [aOR 2.7, 95% CI 1.0–7.0] and diabetes [aOR2.2, 95% CI 1.1–4.5]. Pregnant women with severe maternal outcomes were at higher risk of caesarean section [70.7% (n = 53/75)], preterm delivery [62.7% (n = 32/51)] and newborns requiring admission to the neonatal intensive care unit [41.3% (n = 31/75)]. In this study, several risk factors for developing severe complications of SARS-CoV-2 infection among pregnant women were identified including pulmonary comorbidities, hypertensive disorders and diabetes. Obstetrical and neonatal outcomes appear to be influenced by the severity of maternal disease.https://doi.org/10.1038/s41598-021-92357-y |