Therminator DNA Polymerase: Modified Nucleotides and Unnatural Substrates

Therminator DNA Polymerase: Modified Nucleotides and Unnatural Substrates

A variant of 9°N DNA polymerase [Genbank ID (AAA88769.1)] with three mutations (D141A, E143A, A485L) and commercialized under the name “Therminator DNA polymerase” has the ability to incorporate a variety of modified nucleotide classes. This Review focuses on how Therminator DNA Polymerase has enabl...

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Bibliographic Details
Main Authors: Andrew F. Gardner, Kiserian M. Jackson, Madeleine M. Boyle, Jackson A. Buss, Vladimir Potapov, Alexandra M. Gehring, Kelly M. Zatopek, Ivan R. Corrêa Jr., Jennifer L. Ong, William E. Jack
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Molecular Biosciences
Subjects:
DNA sequencing
xenonucleic acids
aptamers
functionalized DNA
unnatural base pairs
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2019.00028/full

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