Novel polygenic risk score as a translational tool linking depression-related changes in the corticolimbic transcriptome with neural face processing and anhedonic symptoms

Novel polygenic risk score as a translational tool linking depression-related changes in the corticolimbic transcriptome with neural face processing and anhedonic symptoms

Abstract Convergent data from imaging and postmortem brain transcriptome studies implicate corticolimbic circuit (CLC) dysregulation in the pathophysiology of depression. To more directly bridge these lines of work, we generated a novel transcriptome-based polygenic risk score (T-PRS), capturing sub...

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Bibliographic Details
Main Authors: Klara Mareckova, Colin Hawco, Fernanda C. Dos Santos, Arin Bakht, Navona Calarco, Amy E. Miles, Aristotle N. Voineskos, Etienne Sibille, Ahmad R. Hariri, Yuliya S. Nikolova
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-020-01093-w

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https://doi.org/10.1038/s41398-020-01093-w

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