Neuropathic Pain in Children with Sickle Cell Disease: The Hidden Side of the Vaso-Occlusive Crisis
The majority of hospitalizations of patients with sickle cell disease (SCD) are related to painful vaso-occlusive crises (VOCs). Although the pain of VOC is classically nociceptive, neuropathic pain (NP) has also been demonstrated in SCD patients. The aim of our study is to specify the prevalence of...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-01-01
|
Series: | Children |
Subjects: | |
Online Access: | https://www.mdpi.com/2227-9067/8/2/84 |
id |
doaj-dbaffadd6d2f486f95bd82661cad108a |
---|---|
record_format |
Article |
spelling |
doaj-dbaffadd6d2f486f95bd82661cad108a2021-04-02T21:03:24ZengMDPI AGChildren2227-90672021-01-018848410.3390/children8020084Neuropathic Pain in Children with Sickle Cell Disease: The Hidden Side of the Vaso-Occlusive CrisisJeanne Sigalla0Nathalie Duparc Alegria1Enora Le Roux2Artemis Toumazi3Anne-Françoise Thiollier4Laurent Holvoet5Malika Benkerrou6Sophie Dugue7Berengere Koehl8Pain Management Unit, Hôpital Robert Debré, APHP, F-75019 Paris, FrancePain Management Unit, Hôpital Robert Debré, APHP, F-75019 Paris, FranceUnité d’Épidémiologie Clinique, Inserm, CIC 1426, Hôpital Universitaire Robert Debré, AP-HP, Nord-Université de Paris, F-75019 Paris, FranceUnité d’Épidémiologie Clinique, Inserm, CIC 1426, Hôpital Universitaire Robert Debré, AP-HP, Nord-Université de Paris, F-75019 Paris, FrancePain Management Unit, Hôpital Robert Debré, APHP, F-75019 Paris, FranceDepartment of Hematology, Reference Center of Sickle Cell Disease, Hôpital Universitaire Robert Debré, AP-HP, Nord-Université de Paris, F-75019 Paris, FranceUniversité de Paris, ECEVE UMR 1123, Inserm, F-75010 Paris, FrancePain Management Unit, Trousseau Hospital, AP-HP, Sorbonne Université, F-75012 Paris, FranceDepartment of Hematology, Reference Center of Sickle Cell Disease, Hôpital Universitaire Robert Debré, AP-HP, Nord-Université de Paris, F-75019 Paris, FranceThe majority of hospitalizations of patients with sickle cell disease (SCD) are related to painful vaso-occlusive crises (VOCs). Although the pain of VOC is classically nociceptive, neuropathic pain (NP) has also been demonstrated in SCD patients. The aim of our study is to specify the prevalence of NP during VOCs in SCD children using a dedicated scale and to measure its characteristics. We performed a prospective study that included SCD children hospitalized for an acute VOC. The presence of NP was sought with the DN4 scale on the second and fourth days of hospitalization. A total of 54 SCD children were included in the study. Overall, 41% of the patients (<i>n</i> = 22) experienced neuropathic pain during the VOC, mostly at an early stage (Day 2). The median age, the sex ratio, the location of the pain, and the morphine consumption were similar for patients with and without NP. Our study shows that neuropathic pain is very common during VOCs in SCD children. The absence of identified risk factors should prompt us to be vigilant regardless of the patient’s age, sex, and clinical presentation.https://www.mdpi.com/2227-9067/8/2/84sickle cell diseaseneuropathic painvaso-occlusive crisispediatricsDN-4 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jeanne Sigalla Nathalie Duparc Alegria Enora Le Roux Artemis Toumazi Anne-Françoise Thiollier Laurent Holvoet Malika Benkerrou Sophie Dugue Berengere Koehl |
spellingShingle |
Jeanne Sigalla Nathalie Duparc Alegria Enora Le Roux Artemis Toumazi Anne-Françoise Thiollier Laurent Holvoet Malika Benkerrou Sophie Dugue Berengere Koehl Neuropathic Pain in Children with Sickle Cell Disease: The Hidden Side of the Vaso-Occlusive Crisis Children sickle cell disease neuropathic pain vaso-occlusive crisis pediatrics DN-4 |
author_facet |
Jeanne Sigalla Nathalie Duparc Alegria Enora Le Roux Artemis Toumazi Anne-Françoise Thiollier Laurent Holvoet Malika Benkerrou Sophie Dugue Berengere Koehl |
author_sort |
Jeanne Sigalla |
title |
Neuropathic Pain in Children with Sickle Cell Disease: The Hidden Side of the Vaso-Occlusive Crisis |
title_short |
Neuropathic Pain in Children with Sickle Cell Disease: The Hidden Side of the Vaso-Occlusive Crisis |
title_full |
Neuropathic Pain in Children with Sickle Cell Disease: The Hidden Side of the Vaso-Occlusive Crisis |
title_fullStr |
Neuropathic Pain in Children with Sickle Cell Disease: The Hidden Side of the Vaso-Occlusive Crisis |
title_full_unstemmed |
Neuropathic Pain in Children with Sickle Cell Disease: The Hidden Side of the Vaso-Occlusive Crisis |
title_sort |
neuropathic pain in children with sickle cell disease: the hidden side of the vaso-occlusive crisis |
publisher |
MDPI AG |
series |
Children |
issn |
2227-9067 |
publishDate |
2021-01-01 |
description |
The majority of hospitalizations of patients with sickle cell disease (SCD) are related to painful vaso-occlusive crises (VOCs). Although the pain of VOC is classically nociceptive, neuropathic pain (NP) has also been demonstrated in SCD patients. The aim of our study is to specify the prevalence of NP during VOCs in SCD children using a dedicated scale and to measure its characteristics. We performed a prospective study that included SCD children hospitalized for an acute VOC. The presence of NP was sought with the DN4 scale on the second and fourth days of hospitalization. A total of 54 SCD children were included in the study. Overall, 41% of the patients (<i>n</i> = 22) experienced neuropathic pain during the VOC, mostly at an early stage (Day 2). The median age, the sex ratio, the location of the pain, and the morphine consumption were similar for patients with and without NP. Our study shows that neuropathic pain is very common during VOCs in SCD children. The absence of identified risk factors should prompt us to be vigilant regardless of the patient’s age, sex, and clinical presentation. |
topic |
sickle cell disease neuropathic pain vaso-occlusive crisis pediatrics DN-4 |
url |
https://www.mdpi.com/2227-9067/8/2/84 |
work_keys_str_mv |
AT jeannesigalla neuropathicpaininchildrenwithsicklecelldiseasethehiddensideofthevasoocclusivecrisis AT nathalieduparcalegria neuropathicpaininchildrenwithsicklecelldiseasethehiddensideofthevasoocclusivecrisis AT enoraleroux neuropathicpaininchildrenwithsicklecelldiseasethehiddensideofthevasoocclusivecrisis AT artemistoumazi neuropathicpaininchildrenwithsicklecelldiseasethehiddensideofthevasoocclusivecrisis AT annefrancoisethiollier neuropathicpaininchildrenwithsicklecelldiseasethehiddensideofthevasoocclusivecrisis AT laurentholvoet neuropathicpaininchildrenwithsicklecelldiseasethehiddensideofthevasoocclusivecrisis AT malikabenkerrou neuropathicpaininchildrenwithsicklecelldiseasethehiddensideofthevasoocclusivecrisis AT sophiedugue neuropathicpaininchildrenwithsicklecelldiseasethehiddensideofthevasoocclusivecrisis AT berengerekoehl neuropathicpaininchildrenwithsicklecelldiseasethehiddensideofthevasoocclusivecrisis |
_version_ |
1721545801466904576 |