The Effects of Sugammadex on Vitamin D Levels in Rabbits Under General Anesthesia
Objective:Sugammadex is a widely used anesthetic agent for reversing of the non-depolarizing block. It reduces blood levels of steroid compounds by encapsulation. The aim of this study was to investigate the effect of sugammadex on the blood levels of vitamin D levels, which has a steroid structure....
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Galenos Yayinevi
2019-12-01
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http://www.turkosteoporozdergisi.org/archives/archive-detail/article-preview/the-effects-of-sugammadex-on-vitamin-d-levels-in-r/32018
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doaj-dbc4ee1a8fcd469591c206e4f6cfb3b82020-11-25T03:09:35ZengGalenos YayineviTürk Osteoporoz Dergisi2147-26532147-26532019-12-01253889210.4274/tod.galenos.2019.6332513049054The Effects of Sugammadex on Vitamin D Levels in Rabbits Under General AnesthesiaTuğba Hünerel0Hatice Betül Altınışık1 Çanakkale Onsekiz Mart University Faculty of Medicine, Department of Anesthesiology and Reanimation, Çanakkale, Turkey Çanakkale Onsekiz Mart University Faculty of Medicine, Department of Anesthesiology and Reanimation, Çanakkale, Turkey Objective:Sugammadex is a widely used anesthetic agent for reversing of the non-depolarizing block. It reduces blood levels of steroid compounds by encapsulation. The aim of this study was to investigate the effect of sugammadex on the blood levels of vitamin D levels, which has a steroid structure.Materials and Methods:A total of 15 adult male New Zealand white rabbits weighing 2-2.5 kg were randomized into three groups according to decurarization: Group S [sugammadex (16 mg/kg), n=5], group N [neostigmine (0.05 mg/kg), n=5], group C (control group, n=5). Vitamin D levels from venous blood were measured at baseline, 20 minutes and 24 hours after general anesthesia.Results:Mean ± SD vitamin D levels before anesthesia, 20 minutes and 24 hours after anesthesia were 4.42±0.60 ng/mL, 4.93±0.72 ng/mL, and 4.66±0.94 ng/mL for group S, 4.92±0.45 ng/mL, 5.02±0.41 ng/mL, and 5.41±0.56 ng/mL for group N, and 5.15±0.82 ng/mL, 4.57±1.10 ng/mL, and 5.21±1.05 ng/mL for group C, respectively. There were no significant differences in the mean vitamin D levels between the groups at baseline, 20 minutes, and 24 hours.Conclusion:Contrary to expectations, it was found that sugammadex did not have a statistically significant effect on blood levels of vitamin D. http://www.turkosteoporozdergisi.org/archives/archive-detail/article-preview/the-effects-of-sugammadex-on-vitamin-d-levels-in-r/32018 vitamin dgeneral anesthesiasteroidssugammadex |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tuğba Hünerel Hatice Betül Altınışık |
spellingShingle |
Tuğba Hünerel Hatice Betül Altınışık The Effects of Sugammadex on Vitamin D Levels in Rabbits Under General Anesthesia Türk Osteoporoz Dergisi vitamin d general anesthesia steroids sugammadex |
author_facet |
Tuğba Hünerel Hatice Betül Altınışık |
author_sort |
Tuğba Hünerel |
title |
The Effects of Sugammadex on Vitamin D Levels in Rabbits Under General Anesthesia |
title_short |
The Effects of Sugammadex on Vitamin D Levels in Rabbits Under General Anesthesia |
title_full |
The Effects of Sugammadex on Vitamin D Levels in Rabbits Under General Anesthesia |
title_fullStr |
The Effects of Sugammadex on Vitamin D Levels in Rabbits Under General Anesthesia |
title_full_unstemmed |
The Effects of Sugammadex on Vitamin D Levels in Rabbits Under General Anesthesia |
title_sort |
effects of sugammadex on vitamin d levels in rabbits under general anesthesia |
publisher |
Galenos Yayinevi |
series |
Türk Osteoporoz Dergisi |
issn |
2147-2653 2147-2653 |
publishDate |
2019-12-01 |
description |
Objective:Sugammadex is a widely used anesthetic agent for reversing of the non-depolarizing block. It reduces blood levels of steroid compounds by encapsulation. The aim of this study was to investigate the effect of sugammadex on the blood levels of vitamin D levels, which has a steroid structure.Materials and Methods:A total of 15 adult male New Zealand white rabbits weighing 2-2.5 kg were randomized into three groups according to decurarization: Group S [sugammadex (16 mg/kg), n=5], group N [neostigmine (0.05 mg/kg), n=5], group C (control group, n=5). Vitamin D levels from venous blood were measured at baseline, 20 minutes and 24 hours after general anesthesia.Results:Mean ± SD vitamin D levels before anesthesia, 20 minutes and 24 hours after anesthesia were 4.42±0.60 ng/mL, 4.93±0.72 ng/mL, and 4.66±0.94 ng/mL for group S, 4.92±0.45 ng/mL, 5.02±0.41 ng/mL, and 5.41±0.56 ng/mL for group N, and 5.15±0.82 ng/mL, 4.57±1.10 ng/mL, and 5.21±1.05 ng/mL for group C, respectively. There were no significant differences in the mean vitamin D levels between the groups at baseline, 20 minutes, and 24 hours.Conclusion:Contrary to expectations, it was found that sugammadex did not have a statistically significant effect on blood levels of vitamin D. |
topic |
vitamin d general anesthesia steroids sugammadex |
url |
http://www.turkosteoporozdergisi.org/archives/archive-detail/article-preview/the-effects-of-sugammadex-on-vitamin-d-levels-in-r/32018
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