The genotype distribution of hepatitis C in southeastern Taiwan: Clinical characteristics, racial difference, and therapeutic response
The genotypes of hepatitis C virus (HCV) are associated with the therapeutic response. The racial diversity of Taitung, Taiwan is heterogeneous and a distinguishing feature; how such racial differences influence the genotype distribution and treatment outcome has not been well studied. The objective...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2015-11-01
|
Series: | Kaohsiung Journal of Medical Sciences |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1607551X15002119 |
id |
doaj-dbc7d66e696344bc9c5b9fe311c2361e |
---|---|
record_format |
Article |
spelling |
doaj-dbc7d66e696344bc9c5b9fe311c2361e2020-11-25T02:00:33ZengWileyKaohsiung Journal of Medical Sciences1607-551X2015-11-01311159760210.1016/j.kjms.2015.09.006The genotype distribution of hepatitis C in southeastern Taiwan: Clinical characteristics, racial difference, and therapeutic responseChun-Han Cheng0Huan-Lin Chen1I-Tsung Lin2Chia-Hsien Wu3Yuan-Kai Lee4Ming-Wun Wong5Ming-Jong Bair6Division of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Taitung, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Taitung, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Taitung, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Taitung, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Taitung, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Taitung, TaiwanDivision of Gastroenterology, Department of Internal Medicine, Mackay Memorial Hospital, Taitung, TaiwanThe genotypes of hepatitis C virus (HCV) are associated with the therapeutic response. The racial diversity of Taitung, Taiwan is heterogeneous and a distinguishing feature; how such racial differences influence the genotype distribution and treatment outcome has not been well studied. The objective of this study is to elucidate the HCV genotype distribution in southeastern Taiwan and to analyze the racial differences influencing genotypes and clinical implications. In this retrospective cohort study, we included 343 patients who had been treated with peginterferon-alpha plus ribavirin. The predominant HCV genotype in the southeastern area was type 1 (43.7%), followed by type 2 (37.0%). The proportion of patients mixed with genotype 1 was lower in indigenous vis-à-vis nonindigenous groups (46.1% and 60.2%, p = 0.02). The prevalence of genotype 6 (5.2%) seems higher than in the general population of Taiwan and showed no difference between indigenous and nonindigenous people. The sustained virological response rate was higher in patients without genotype 1, low baseline HCV RNA (≤ 400,000 IU/mL), and in patients who achieved rapid virological response. Racial differences did not influence the therapeutic response. In this retrospective study, the proportion of HCV genotype 6 appeared slightly higher in southeastern areas than in the general population in Taiwan. The prevalence of genotype 1 in indigenous people was statistically lower than in nonindigenous people. Sustained virological response rate did not show any significant difference between indigenous and nonindigenous people in the current study.http://www.sciencedirect.com/science/article/pii/S1607551X15002119AustronesianEthnic groupGenotypeHepatitis CTherapeutics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chun-Han Cheng Huan-Lin Chen I-Tsung Lin Chia-Hsien Wu Yuan-Kai Lee Ming-Wun Wong Ming-Jong Bair |
spellingShingle |
Chun-Han Cheng Huan-Lin Chen I-Tsung Lin Chia-Hsien Wu Yuan-Kai Lee Ming-Wun Wong Ming-Jong Bair The genotype distribution of hepatitis C in southeastern Taiwan: Clinical characteristics, racial difference, and therapeutic response Kaohsiung Journal of Medical Sciences Austronesian Ethnic group Genotype Hepatitis C Therapeutics |
author_facet |
Chun-Han Cheng Huan-Lin Chen I-Tsung Lin Chia-Hsien Wu Yuan-Kai Lee Ming-Wun Wong Ming-Jong Bair |
author_sort |
Chun-Han Cheng |
title |
The genotype distribution of hepatitis C in southeastern Taiwan: Clinical characteristics, racial difference, and therapeutic response |
title_short |
The genotype distribution of hepatitis C in southeastern Taiwan: Clinical characteristics, racial difference, and therapeutic response |
title_full |
The genotype distribution of hepatitis C in southeastern Taiwan: Clinical characteristics, racial difference, and therapeutic response |
title_fullStr |
The genotype distribution of hepatitis C in southeastern Taiwan: Clinical characteristics, racial difference, and therapeutic response |
title_full_unstemmed |
The genotype distribution of hepatitis C in southeastern Taiwan: Clinical characteristics, racial difference, and therapeutic response |
title_sort |
genotype distribution of hepatitis c in southeastern taiwan: clinical characteristics, racial difference, and therapeutic response |
publisher |
Wiley |
series |
Kaohsiung Journal of Medical Sciences |
issn |
1607-551X |
publishDate |
2015-11-01 |
description |
The genotypes of hepatitis C virus (HCV) are associated with the therapeutic response. The racial diversity of Taitung, Taiwan is heterogeneous and a distinguishing feature; how such racial differences influence the genotype distribution and treatment outcome has not been well studied. The objective of this study is to elucidate the HCV genotype distribution in southeastern Taiwan and to analyze the racial differences influencing genotypes and clinical implications. In this retrospective cohort study, we included 343 patients who had been treated with peginterferon-alpha plus ribavirin. The predominant HCV genotype in the southeastern area was type 1 (43.7%), followed by type 2 (37.0%). The proportion of patients mixed with genotype 1 was lower in indigenous vis-à-vis nonindigenous groups (46.1% and 60.2%, p = 0.02). The prevalence of genotype 6 (5.2%) seems higher than in the general population of Taiwan and showed no difference between indigenous and nonindigenous people. The sustained virological response rate was higher in patients without genotype 1, low baseline HCV RNA (≤ 400,000 IU/mL), and in patients who achieved rapid virological response. Racial differences did not influence the therapeutic response. In this retrospective study, the proportion of HCV genotype 6 appeared slightly higher in southeastern areas than in the general population in Taiwan. The prevalence of genotype 1 in indigenous people was statistically lower than in nonindigenous people. Sustained virological response rate did not show any significant difference between indigenous and nonindigenous people in the current study. |
topic |
Austronesian Ethnic group Genotype Hepatitis C Therapeutics |
url |
http://www.sciencedirect.com/science/article/pii/S1607551X15002119 |
work_keys_str_mv |
AT chunhancheng thegenotypedistributionofhepatitiscinsoutheasterntaiwanclinicalcharacteristicsracialdifferenceandtherapeuticresponse AT huanlinchen thegenotypedistributionofhepatitiscinsoutheasterntaiwanclinicalcharacteristicsracialdifferenceandtherapeuticresponse AT itsunglin thegenotypedistributionofhepatitiscinsoutheasterntaiwanclinicalcharacteristicsracialdifferenceandtherapeuticresponse AT chiahsienwu thegenotypedistributionofhepatitiscinsoutheasterntaiwanclinicalcharacteristicsracialdifferenceandtherapeuticresponse AT yuankailee thegenotypedistributionofhepatitiscinsoutheasterntaiwanclinicalcharacteristicsracialdifferenceandtherapeuticresponse AT mingwunwong thegenotypedistributionofhepatitiscinsoutheasterntaiwanclinicalcharacteristicsracialdifferenceandtherapeuticresponse AT mingjongbair thegenotypedistributionofhepatitiscinsoutheasterntaiwanclinicalcharacteristicsracialdifferenceandtherapeuticresponse AT chunhancheng genotypedistributionofhepatitiscinsoutheasterntaiwanclinicalcharacteristicsracialdifferenceandtherapeuticresponse AT huanlinchen genotypedistributionofhepatitiscinsoutheasterntaiwanclinicalcharacteristicsracialdifferenceandtherapeuticresponse AT itsunglin genotypedistributionofhepatitiscinsoutheasterntaiwanclinicalcharacteristicsracialdifferenceandtherapeuticresponse AT chiahsienwu genotypedistributionofhepatitiscinsoutheasterntaiwanclinicalcharacteristicsracialdifferenceandtherapeuticresponse AT yuankailee genotypedistributionofhepatitiscinsoutheasterntaiwanclinicalcharacteristicsracialdifferenceandtherapeuticresponse AT mingwunwong genotypedistributionofhepatitiscinsoutheasterntaiwanclinicalcharacteristicsracialdifferenceandtherapeuticresponse AT mingjongbair genotypedistributionofhepatitiscinsoutheasterntaiwanclinicalcharacteristicsracialdifferenceandtherapeuticresponse |
_version_ |
1724959817334784000 |