MicroRNA-34a enhances T cell activation by targeting diacylglycerol kinase ζ.
The engagement of the T cell receptor (TCR) induces the generation of diacylglycerol (DAG), an important second messenger activating both the Ras/Erk and PKCθ/NFκB pathways. DAG kinases (DGKs) participate in the metabolism of DAG by converting it to phosphatidic acid. DGKζ has been demonstrated to b...
Main Authors: | Jinwook Shin, Danli Xie, Xiao-Ping Zhong |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3798301?pdf=render |
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