Structure and Function of Caliciviral RNA Polymerases

Caliciviruses are a leading agent of human and animal gastroenteritis and respiratory tract infections, which are growing concerns in immunocompromised individuals. However, no vaccines or therapeutics are yet available. Since the rapid rate of genetic evolution of caliciviruses is mainly due to the...

Full description

Bibliographic Details
Main Authors:	Ji-Hye Lee, Mi Sook Chung, Kyung Hyun Kim
Format:	Article
Language:	English
Published:	MDPI AG 2017-11-01
Series:	Viruses
Subjects:	calicivirus polymerase structure interaction precursor
Online Access:	https://www.mdpi.com/1999-4915/9/11/329

id	doaj-dbca803528344c02bcd92db9807227f5
record_format	Article
spelling	doaj-dbca803528344c02bcd92db9807227f52020-11-24T23:54:56ZengMDPI AGViruses1999-49152017-11-0191132910.3390/v9110329v9110329Structure and Function of Caliciviral RNA PolymerasesJi-Hye Lee0Mi Sook Chung1Kyung Hyun Kim2Department of Biotechnology and Bioinformatics, Korea University, Sejong 30019, KoreaDepartment of Food and Nutrition, Duksung Women’s University, Seoul 01369, KoreaDepartment of Biotechnology and Bioinformatics, Korea University, Sejong 30019, KoreaCaliciviruses are a leading agent of human and animal gastroenteritis and respiratory tract infections, which are growing concerns in immunocompromised individuals. However, no vaccines or therapeutics are yet available. Since the rapid rate of genetic evolution of caliciviruses is mainly due to the error-prone nature of RNA-dependent RNA polymerase (RdRp), this article focuses on recent studies of the structures and functions of RdRp from caliciviruses. It also provides recent advances in the interactions of RdRp with virion protein genome-linked (VPg) and RNA and the structural and functional features of its precursor.https://www.mdpi.com/1999-4915/9/11/329caliciviruspolymerasestructureinteractionprecursor
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ji-Hye Lee Mi Sook Chung Kyung Hyun Kim
spellingShingle	Ji-Hye Lee Mi Sook Chung Kyung Hyun Kim Structure and Function of Caliciviral RNA Polymerases Viruses calicivirus polymerase structure interaction precursor
author_facet	Ji-Hye Lee Mi Sook Chung Kyung Hyun Kim
author_sort	Ji-Hye Lee
title	Structure and Function of Caliciviral RNA Polymerases
title_short	Structure and Function of Caliciviral RNA Polymerases
title_full	Structure and Function of Caliciviral RNA Polymerases
title_fullStr	Structure and Function of Caliciviral RNA Polymerases
title_full_unstemmed	Structure and Function of Caliciviral RNA Polymerases
title_sort	structure and function of caliciviral rna polymerases
publisher	MDPI AG
series	Viruses
issn	1999-4915
publishDate	2017-11-01
description	Caliciviruses are a leading agent of human and animal gastroenteritis and respiratory tract infections, which are growing concerns in immunocompromised individuals. However, no vaccines or therapeutics are yet available. Since the rapid rate of genetic evolution of caliciviruses is mainly due to the error-prone nature of RNA-dependent RNA polymerase (RdRp), this article focuses on recent studies of the structures and functions of RdRp from caliciviruses. It also provides recent advances in the interactions of RdRp with virion protein genome-linked (VPg) and RNA and the structural and functional features of its precursor.
topic	calicivirus polymerase structure interaction precursor
url	https://www.mdpi.com/1999-4915/9/11/329
work_keys_str_mv	AT jihyelee structureandfunctionofcaliciviralrnapolymerases AT misookchung structureandfunctionofcaliciviralrnapolymerases AT kyunghyunkim structureandfunctionofcaliciviralrnapolymerases
_version_	1725464315464515584

Structure and Function of Caliciviral RNA Polymerases

Similar Items