Phosphatase PTPN22 Regulates Dendritic Cell Homeostasis and cDC2 Dependent T Cell Responses

Phosphatase PTPN22 Regulates Dendritic Cell Homeostasis and cDC2 Dependent T Cell Responses

Dendritic cells (DCs) are specialized antigen presenting cells that instruct T cell responses through sensing environmental and inflammatory danger signals. Maintaining the homeostasis of the multiple functionally distinct conventional dendritic cells (cDC) subsets that exist in vivo is crucial for...

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Bibliographic Details
Main Authors: Harriet A. Purvis, Fiona Clarke, Anna B. Montgomery, Chloe Colas, Jack A. Bibby, Georgina H. Cornish, Xuezhi Dai, Diana Dudziak, David J. Rawlings, Rose Zamoyska, Pierre Guermonprez, Andrew P. Cope
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
dendritic cell
PTPN22
homeostasis
T follicular helper cell
proliferation
autoimmunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00376/full

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