Impact of Clinical Response to Neoadjuvant Chemotherapy in the Era of Robot Assisted Radical Cystectomy: Results of a Single-Center Experience
Background: Response to neoadjuvant chemotherapy (NACT) has been proven to be an established prognostic factor after open radical cystectomy (ORC). We evaluated the impact of NACT on survival outcomes of a single-institution robotic radical cystectomy (RARC) series. Methods: From January 2012 to Jun...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-08-01
|
Series: | Journal of Clinical Medicine |
Subjects: | |
Online Access: | https://www.mdpi.com/2077-0383/9/9/2736 |
id |
doaj-dbd20f76a35b4126afab7bb6295832a8 |
---|---|
record_format |
Article |
spelling |
doaj-dbd20f76a35b4126afab7bb6295832a82020-11-25T03:40:07ZengMDPI AGJournal of Clinical Medicine2077-03832020-08-0192736273610.3390/jcm9092736Impact of Clinical Response to Neoadjuvant Chemotherapy in the Era of Robot Assisted Radical Cystectomy: Results of a Single-Center ExperienceUmberto Anceschi0Aldo Brassetti1Gabriele Tuderti2Maria Consiglia Ferriero3Manuela Costantini4Alfredo Maria Bove5Fabio Calabrò6Paolo Carlini7Sabrina Vari8Riccardo Mastroianni9Michele Gallucci10Giuseppe Simone11Department of Urology, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, ItalyDepartment of Urology, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, ItalyDepartment of Urology, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, ItalyDepartment of Urology, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, ItalyDepartment of Urology, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, ItalyDepartment of Urology, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, ItalyDepartment of Oncology, San Camillo-Forlanini Hospital, Rome, Circonvallazione Gianicolense 87, 00152 Rome, ItalyDepartment of Oncology, Regina Elena National Cancer Institute, Rome, Via Elio Chianesi 53, 00144 Rome, ItalyDepartment of Oncology, Regina Elena National Cancer Institute, Rome, Via Elio Chianesi 53, 00144 Rome, ItalyDepartment of Urology, University of Rome, La Sapienza, Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Urology, University of Rome, La Sapienza, Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Urology, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, ItalyBackground: Response to neoadjuvant chemotherapy (NACT) has been proven to be an established prognostic factor after open radical cystectomy (ORC). We evaluated the impact of NACT on survival outcomes of a single-institution robotic radical cystectomy (RARC) series. Methods: From January 2012 to June 2020, 79 patients were identified. Baseline, demographic, perioperative, and pathologic data were described. Kaplan–Meier with the log-rank test was used to compare overall survival (OS) differences between complete, partial, and no-NACT responders, respectively. Univariable and multivariable regression analyses were performed to identify predictors of OS. Results: Complete, partial, and absent response to NACT were recorded in 43 (54.4%), 21 (19%), and 15 (26.6%) patients, respectively. A complete response to NACT displayed a trend toward significant higher OS (<i>p </i>=<i> </i>0.03). In univariable analysis, significant predictors of lower OS were hypertension (HR 3.37; CI 95% 1.31–8.62; <i>p </i>=<i> </i>0.01); advanced nodal involvement (HR 2.41; CI 95% 0.53–10.9; <i>p </i><<i> </i>0.001); and incomplete response to NACT (HR 0.41; CI 95% 0.18–0.95; <i>p </i>=<i> </i>0.039). In multivariable analysis, the only independent predictor of worse OS was advanced pathologic N stages (HR 10.1; CI: 95% CI 2.3–44.3; <i>p </i>=<i> </i>0.002). Conclusions: Complete response to NACT is associated with increased OS probability, but significant nodal residual disease remains the only independent predictor of OS after RARC.https://www.mdpi.com/2077-0383/9/9/2736neoadjuvant chemotherapyclinical responserobotic radical cystectomymuscle-invasive bladder cancerlymphadenectomyoverall survival |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Umberto Anceschi Aldo Brassetti Gabriele Tuderti Maria Consiglia Ferriero Manuela Costantini Alfredo Maria Bove Fabio Calabrò Paolo Carlini Sabrina Vari Riccardo Mastroianni Michele Gallucci Giuseppe Simone |
spellingShingle |
Umberto Anceschi Aldo Brassetti Gabriele Tuderti Maria Consiglia Ferriero Manuela Costantini Alfredo Maria Bove Fabio Calabrò Paolo Carlini Sabrina Vari Riccardo Mastroianni Michele Gallucci Giuseppe Simone Impact of Clinical Response to Neoadjuvant Chemotherapy in the Era of Robot Assisted Radical Cystectomy: Results of a Single-Center Experience Journal of Clinical Medicine neoadjuvant chemotherapy clinical response robotic radical cystectomy muscle-invasive bladder cancer lymphadenectomy overall survival |
author_facet |
Umberto Anceschi Aldo Brassetti Gabriele Tuderti Maria Consiglia Ferriero Manuela Costantini Alfredo Maria Bove Fabio Calabrò Paolo Carlini Sabrina Vari Riccardo Mastroianni Michele Gallucci Giuseppe Simone |
author_sort |
Umberto Anceschi |
title |
Impact of Clinical Response to Neoadjuvant Chemotherapy in the Era of Robot Assisted Radical Cystectomy: Results of a Single-Center Experience |
title_short |
Impact of Clinical Response to Neoadjuvant Chemotherapy in the Era of Robot Assisted Radical Cystectomy: Results of a Single-Center Experience |
title_full |
Impact of Clinical Response to Neoadjuvant Chemotherapy in the Era of Robot Assisted Radical Cystectomy: Results of a Single-Center Experience |
title_fullStr |
Impact of Clinical Response to Neoadjuvant Chemotherapy in the Era of Robot Assisted Radical Cystectomy: Results of a Single-Center Experience |
title_full_unstemmed |
Impact of Clinical Response to Neoadjuvant Chemotherapy in the Era of Robot Assisted Radical Cystectomy: Results of a Single-Center Experience |
title_sort |
impact of clinical response to neoadjuvant chemotherapy in the era of robot assisted radical cystectomy: results of a single-center experience |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-08-01 |
description |
Background: Response to neoadjuvant chemotherapy (NACT) has been proven to be an established prognostic factor after open radical cystectomy (ORC). We evaluated the impact of NACT on survival outcomes of a single-institution robotic radical cystectomy (RARC) series. Methods: From January 2012 to June 2020, 79 patients were identified. Baseline, demographic, perioperative, and pathologic data were described. Kaplan–Meier with the log-rank test was used to compare overall survival (OS) differences between complete, partial, and no-NACT responders, respectively. Univariable and multivariable regression analyses were performed to identify predictors of OS. Results: Complete, partial, and absent response to NACT were recorded in 43 (54.4%), 21 (19%), and 15 (26.6%) patients, respectively. A complete response to NACT displayed a trend toward significant higher OS (<i>p </i>=<i> </i>0.03). In univariable analysis, significant predictors of lower OS were hypertension (HR 3.37; CI 95% 1.31–8.62; <i>p </i>=<i> </i>0.01); advanced nodal involvement (HR 2.41; CI 95% 0.53–10.9; <i>p </i><<i> </i>0.001); and incomplete response to NACT (HR 0.41; CI 95% 0.18–0.95; <i>p </i>=<i> </i>0.039). In multivariable analysis, the only independent predictor of worse OS was advanced pathologic N stages (HR 10.1; CI: 95% CI 2.3–44.3; <i>p </i>=<i> </i>0.002). Conclusions: Complete response to NACT is associated with increased OS probability, but significant nodal residual disease remains the only independent predictor of OS after RARC. |
topic |
neoadjuvant chemotherapy clinical response robotic radical cystectomy muscle-invasive bladder cancer lymphadenectomy overall survival |
url |
https://www.mdpi.com/2077-0383/9/9/2736 |
work_keys_str_mv |
AT umbertoanceschi impactofclinicalresponsetoneoadjuvantchemotherapyintheeraofrobotassistedradicalcystectomyresultsofasinglecenterexperience AT aldobrassetti impactofclinicalresponsetoneoadjuvantchemotherapyintheeraofrobotassistedradicalcystectomyresultsofasinglecenterexperience AT gabrieletuderti impactofclinicalresponsetoneoadjuvantchemotherapyintheeraofrobotassistedradicalcystectomyresultsofasinglecenterexperience AT mariaconsigliaferriero impactofclinicalresponsetoneoadjuvantchemotherapyintheeraofrobotassistedradicalcystectomyresultsofasinglecenterexperience AT manuelacostantini impactofclinicalresponsetoneoadjuvantchemotherapyintheeraofrobotassistedradicalcystectomyresultsofasinglecenterexperience AT alfredomariabove impactofclinicalresponsetoneoadjuvantchemotherapyintheeraofrobotassistedradicalcystectomyresultsofasinglecenterexperience AT fabiocalabro impactofclinicalresponsetoneoadjuvantchemotherapyintheeraofrobotassistedradicalcystectomyresultsofasinglecenterexperience AT paolocarlini impactofclinicalresponsetoneoadjuvantchemotherapyintheeraofrobotassistedradicalcystectomyresultsofasinglecenterexperience AT sabrinavari impactofclinicalresponsetoneoadjuvantchemotherapyintheeraofrobotassistedradicalcystectomyresultsofasinglecenterexperience AT riccardomastroianni impactofclinicalresponsetoneoadjuvantchemotherapyintheeraofrobotassistedradicalcystectomyresultsofasinglecenterexperience AT michelegallucci impactofclinicalresponsetoneoadjuvantchemotherapyintheeraofrobotassistedradicalcystectomyresultsofasinglecenterexperience AT giuseppesimone impactofclinicalresponsetoneoadjuvantchemotherapyintheeraofrobotassistedradicalcystectomyresultsofasinglecenterexperience |
_version_ |
1724536239734915072 |