Glioblastoma Mimicking Viral Encephalitis Responds to Acyclovir: A Case Series and Literature Review
Viral encephalitis and glioblastoma are both relatively rare conditions with poor prognoses. While the clinical and radiographic presentations of these diseases are often distinctly different, viral encephalitis can sometimes masquerade as glioblastoma. Rarely, glioblastoma can also be misdiagnosed...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2019-01-01
|
Series: | Frontiers in Oncology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2019.00008/full |
id |
doaj-dbd55fb227444c80ab0609117749d68b |
---|---|
record_format |
Article |
spelling |
doaj-dbd55fb227444c80ab0609117749d68b2020-11-25T02:29:15ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2019-01-01910.3389/fonc.2019.00008413917Glioblastoma Mimicking Viral Encephalitis Responds to Acyclovir: A Case Series and Literature ReviewKeenan Piper0Haidn Foster1Haidn Foster2Brandon Gabel3Burt Nabors4Charles Cobbs5Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA, United StatesBen and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA, United StatesUniversity of Cincinnati College of Medicine, Cincinnati, OH, United StatesDepartment of Neurological Surgery, University of California San Diego Medical Center, San Diego, CA, United StatesDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, United StatesBen and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA, United StatesViral encephalitis and glioblastoma are both relatively rare conditions with poor prognoses. While the clinical and radiographic presentations of these diseases are often distinctly different, viral encephalitis can sometimes masquerade as glioblastoma. Rarely, glioblastoma can also be misdiagnosed as viral encephalitis. In some cases where a high-grade glioma was initially diagnosed as viral encephalitis, antiviral administration has proven effective for relieving early symptoms. We present three cases in which patients presented with symptoms and radiographic findings suggestive of viral encephalitis and experienced dramatic clinical improvement following treatment with acyclovir, only to later be diagnosed with glioblastoma in the region of suspected encephalitis and ultimately succumb to tumor progression.https://www.frontiersin.org/article/10.3389/fonc.2019.00008/fullglioblastomaGBMgliomaencephalitisviral encephalitisherpes simplex encephalitis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Keenan Piper Haidn Foster Haidn Foster Brandon Gabel Burt Nabors Charles Cobbs |
spellingShingle |
Keenan Piper Haidn Foster Haidn Foster Brandon Gabel Burt Nabors Charles Cobbs Glioblastoma Mimicking Viral Encephalitis Responds to Acyclovir: A Case Series and Literature Review Frontiers in Oncology glioblastoma GBM glioma encephalitis viral encephalitis herpes simplex encephalitis |
author_facet |
Keenan Piper Haidn Foster Haidn Foster Brandon Gabel Burt Nabors Charles Cobbs |
author_sort |
Keenan Piper |
title |
Glioblastoma Mimicking Viral Encephalitis Responds to Acyclovir: A Case Series and Literature Review |
title_short |
Glioblastoma Mimicking Viral Encephalitis Responds to Acyclovir: A Case Series and Literature Review |
title_full |
Glioblastoma Mimicking Viral Encephalitis Responds to Acyclovir: A Case Series and Literature Review |
title_fullStr |
Glioblastoma Mimicking Viral Encephalitis Responds to Acyclovir: A Case Series and Literature Review |
title_full_unstemmed |
Glioblastoma Mimicking Viral Encephalitis Responds to Acyclovir: A Case Series and Literature Review |
title_sort |
glioblastoma mimicking viral encephalitis responds to acyclovir: a case series and literature review |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2019-01-01 |
description |
Viral encephalitis and glioblastoma are both relatively rare conditions with poor prognoses. While the clinical and radiographic presentations of these diseases are often distinctly different, viral encephalitis can sometimes masquerade as glioblastoma. Rarely, glioblastoma can also be misdiagnosed as viral encephalitis. In some cases where a high-grade glioma was initially diagnosed as viral encephalitis, antiviral administration has proven effective for relieving early symptoms. We present three cases in which patients presented with symptoms and radiographic findings suggestive of viral encephalitis and experienced dramatic clinical improvement following treatment with acyclovir, only to later be diagnosed with glioblastoma in the region of suspected encephalitis and ultimately succumb to tumor progression. |
topic |
glioblastoma GBM glioma encephalitis viral encephalitis herpes simplex encephalitis |
url |
https://www.frontiersin.org/article/10.3389/fonc.2019.00008/full |
work_keys_str_mv |
AT keenanpiper glioblastomamimickingviralencephalitisrespondstoacycloviracaseseriesandliteraturereview AT haidnfoster glioblastomamimickingviralencephalitisrespondstoacycloviracaseseriesandliteraturereview AT haidnfoster glioblastomamimickingviralencephalitisrespondstoacycloviracaseseriesandliteraturereview AT brandongabel glioblastomamimickingviralencephalitisrespondstoacycloviracaseseriesandliteraturereview AT burtnabors glioblastomamimickingviralencephalitisrespondstoacycloviracaseseriesandliteraturereview AT charlescobbs glioblastomamimickingviralencephalitisrespondstoacycloviracaseseriesandliteraturereview |
_version_ |
1724834312677752832 |