The value of intraoperative ultrasonography during the resection of relapsed irradiated malignant gliomas in the brain
Purpose The aim of this study was to investigate whether intraoperative ultrasonography (IOUS) helped the surgeon navigate towards the tumor as seen in preoperative magnetic resonance imaging and whether IOUS was able to distinguish between tumor margins and the surrounding tissue. Methods Twenty-fi...
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doaj-dbd6b64b40da441f8a5270eb4ab264412020-11-25T00:49:19ZengKorean Society of Ultrasound in MedicineUltrasonography2288-59192288-59432017-01-01361606510.14366/usg.16015146The value of intraoperative ultrasonography during the resection of relapsed irradiated malignant gliomas in the brainKay Mursch0Martin Scholz1Wolfgang Brück2Julianne Behnke-Mursch3 Department of Neurosurgery, Zentralklinik, Bad Berka, Germany Department of Neurosurgery, Klinikum Duisburg, Duisburg, Germany Department of Neuropathology, Georg August Universität, Göttingen, Germany Department of Neurosurgery, Zentralklinik, Bad Berka, GermanyPurpose The aim of this study was to investigate whether intraoperative ultrasonography (IOUS) helped the surgeon navigate towards the tumor as seen in preoperative magnetic resonance imaging and whether IOUS was able to distinguish between tumor margins and the surrounding tissue. Methods Twenty-five patients suffering from high-grade gliomas who were previously treated by surgery and radiotherapy were included. Intraoperatively, two histopathologic samples were obtained a sample of unequivocal tumor tissue (according to anatomical landmarks and the surgeon’s visual and tactile impressions) and a small tissue sample obtained using a navigated needle when the surgeon decided to stop the resection. This specimen was considered to be a boundary specimen, where no tumor tissue was apparent. The decision to take the second sample was not influenced by IOUS. The effect of IOUS was analyzed semi-quantitatively. Results All 25 samples of unequivocal tumor tissue were histopathologically classified as tumor tissue and were hyperechoic on IOUS. Of the boundary specimens, eight were hypoechoic. Only one harbored tumor tissue (P=0.150). Seventeen boundaries were moderately hyperechoic, and these samples contained all possible histological results (i.e., tumor, infiltration, or no tumor). Conclusion During surgery performed on relapsed, irradiated, high-grade gliomas, IOUS provided a reliable method of navigating towards the core of the tumor. At borders, it did not reliably distinguish between remnants or tumor-free tissue, but hypoechoic areas seldom contained tumor tissue.http://e-ultrasonography.org/upload/usg-16015.pdfGlioblastomaGliomaInterventional ultrasonographyNeoplasms, residualNeurosurgical procedure |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kay Mursch Martin Scholz Wolfgang Brück Julianne Behnke-Mursch |
spellingShingle |
Kay Mursch Martin Scholz Wolfgang Brück Julianne Behnke-Mursch The value of intraoperative ultrasonography during the resection of relapsed irradiated malignant gliomas in the brain Ultrasonography Glioblastoma Glioma Interventional ultrasonography Neoplasms, residual Neurosurgical procedure |
author_facet |
Kay Mursch Martin Scholz Wolfgang Brück Julianne Behnke-Mursch |
author_sort |
Kay Mursch |
title |
The value of intraoperative ultrasonography during the resection of relapsed irradiated malignant gliomas in the brain |
title_short |
The value of intraoperative ultrasonography during the resection of relapsed irradiated malignant gliomas in the brain |
title_full |
The value of intraoperative ultrasonography during the resection of relapsed irradiated malignant gliomas in the brain |
title_fullStr |
The value of intraoperative ultrasonography during the resection of relapsed irradiated malignant gliomas in the brain |
title_full_unstemmed |
The value of intraoperative ultrasonography during the resection of relapsed irradiated malignant gliomas in the brain |
title_sort |
value of intraoperative ultrasonography during the resection of relapsed irradiated malignant gliomas in the brain |
publisher |
Korean Society of Ultrasound in Medicine |
series |
Ultrasonography |
issn |
2288-5919 2288-5943 |
publishDate |
2017-01-01 |
description |
Purpose The aim of this study was to investigate whether intraoperative ultrasonography (IOUS) helped the surgeon navigate towards the tumor as seen in preoperative magnetic resonance imaging and whether IOUS was able to distinguish between tumor margins and the surrounding tissue. Methods Twenty-five patients suffering from high-grade gliomas who were previously treated by surgery and radiotherapy were included. Intraoperatively, two histopathologic samples were obtained a sample of unequivocal tumor tissue (according to anatomical landmarks and the surgeon’s visual and tactile impressions) and a small tissue sample obtained using a navigated needle when the surgeon decided to stop the resection. This specimen was considered to be a boundary specimen, where no tumor tissue was apparent. The decision to take the second sample was not influenced by IOUS. The effect of IOUS was analyzed semi-quantitatively. Results All 25 samples of unequivocal tumor tissue were histopathologically classified as tumor tissue and were hyperechoic on IOUS. Of the boundary specimens, eight were hypoechoic. Only one harbored tumor tissue (P=0.150). Seventeen boundaries were moderately hyperechoic, and these samples contained all possible histological results (i.e., tumor, infiltration, or no tumor). Conclusion During surgery performed on relapsed, irradiated, high-grade gliomas, IOUS provided a reliable method of navigating towards the core of the tumor. At borders, it did not reliably distinguish between remnants or tumor-free tissue, but hypoechoic areas seldom contained tumor tissue. |
topic |
Glioblastoma Glioma Interventional ultrasonography Neoplasms, residual Neurosurgical procedure |
url |
http://e-ultrasonography.org/upload/usg-16015.pdf |
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