Tracing sub-structure in the European American population with PCA-informative markers.

Tracing sub-structure in the European American population with PCA-informative markers.

Genetic structure in the European American population reflects waves of migration and recent gene flow among different populations. This complex structure can introduce bias in genetic association studies. Using Principal Components Analysis (PCA), we analyze the structure of two independent Europea...

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Bibliographic Details
Main Authors: Peristera Paschou, Petros Drineas, Jamey Lewis, Caroline M Nievergelt, Deborah A Nickerson, Joshua D Smith, Paul M Ridker, Daniel I Chasman, Ronald M Krauss, Elad Ziv
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2537989?pdf=render

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