Soluble interleukin-15 complexes are generated in vivo by type I interferon dependent and independent pathways.
Interleukin (IL)-15 associates with IL-15Rα on the cell surface where it can be cleaved into soluble cytokine/receptor complexes that have the potential to stimulate CD8 T cells and NK cells. Unfortunately, little is known about the in vivo production of soluble IL-15Rα/IL-15 complexes (sIL-15 compl...
Main Authors: | Scott M Anthony, Megan E Howard, Yared Hailemichael, Willem W Overwijk, Kimberly S Schluns |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
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Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0120274 |
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