Soluble interleukin-15 complexes are generated in vivo by type I interferon dependent and independent pathways.

Soluble interleukin-15 complexes are generated in vivo by type I interferon dependent and independent pathways.

Interleukin (IL)-15 associates with IL-15Rα on the cell surface where it can be cleaved into soluble cytokine/receptor complexes that have the potential to stimulate CD8 T cells and NK cells. Unfortunately, little is known about the in vivo production of soluble IL-15Rα/IL-15 complexes (sIL-15 compl...

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Bibliographic Details
Main Authors:	Scott M Anthony, Megan E Howard, Yared Hailemichael, Willem W Overwijk, Kimberly S Schluns
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2015-01-01
Series:	PLoS ONE
Online Access:	https://doi.org/10.1371/journal.pone.0120274

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