Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level

Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level

Mammalian oocytes are arrested in the dictyate stage of meiotic prophase I for long periods of time, during which the high concentration of the p53 family member TAp63α sensitizes them to DNA damage-induced apoptosis. TAp63α is kept in an inactive and exclusively dimeric state but undergoes rapid ph...

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Bibliographic Details
Main Authors: Daniel Coutandin, Christian Osterburg, Ratnesh Kumar Srivastav, Manuela Sumyk, Sebastian Kehrloesser, Jakob Gebel, Marcel Tuppi, Jens Hannewald, Birgit Schäfer, Eidarus Salah, Sebastian Mathea, Uta Müller-Kuller, James Doutch, Manuel Grez, Stefan Knapp, Volker Dötsch
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-03-01
Series:eLife
Subjects:
DNA damage
kinetically trapped state
p63
quality control
oocytes
spring-loaded activation
Online Access:https://elifesciences.org/articles/13909

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