A New Rabbit-Skin Model to Evaluate Protective Efficacy of Tuberculosis Vaccines

A New Rabbit-Skin Model to Evaluate Protective Efficacy of Tuberculosis Vaccines

Background: BCG protection is suboptimal and there is significant interest to develop new tuberculosis (TB) vaccines. However, there are significant limitations of the current vaccine evaluation systems in the mouse model. Here, we developed a BCG-challenge rabbit skin model as a new way to evaluate...

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Bibliographic Details
Main Authors: Huiyu Chen, Xun Liu, Xingming Ma, Qian Wang, Guang Yang, Hongxia Niu, Shuaixiang Li, Bingzheng He, Shanshan He, Arthur M. Dannenberg, Bingdong Zhu, Ying Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Microbiology
Subjects:
tuberculosis
subunit vaccine
BCG
rabbit skin model
pathology
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.00842/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.00842/full

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