G10 is a direct activator of human STING
The cGAS/STING pathway initiates an innate immune response when DNA is detected in the cytosol. DNA bound cGAS synthesizes cyclic dinucleotides which bind and activate the adaptor STING, leading to downstream secretion of Type I interferons and other pro-inflammatory NFκB pathway cytokines. In the m...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482845/?tool=EBI |
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by Monali Banerjee, Sandip Middya, Ritesh Shrivastava, Sourav Basu, Rajib Ghosh, David C Pryde, Dharmendra B Yadav, Arjun Surya
Published 2020-01-01
Get full textPublished 2020-01-01
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