Involvement of organic cation transporter-3 and plasma membrane monoamine transporter in serotonin uptake in human brain vascular smooth muscle cells

Involvement of organic cation transporter-3 and plasma membrane monoamine transporter in serotonin uptake in human brain vascular smooth muscle cells

The serotonin (5-HT) uptake system is supposed to play a crucial part in vascular functions by fine-tuning the local concentration of 5-HT in the vicinity of 5-HT2 receptors in vascular smooth muscle cells. In this study, the mechanism of 5-HT uptake in human brain vascular smooth muscle cells (HBVS...

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Bibliographic Details
Main Authors: Rachel Wai-sum Li, Cui eYang, Yiu-Wa eKwan, Shun-Wan eChan, Simon Ming-Yuen Lee, George Pak-Heng Leung
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-02-01
Series:Frontiers in Pharmacology
Subjects:
Brain
Serotonin
vascular smooth muscle cells
organic cation transporter
monoamine transporter
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00014/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00014/full

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