Dural lymphatics regulate clearance of extracellular tau from the CNS

Dural lymphatics regulate clearance of extracellular tau from the CNS

Abstract Background Alzheimer’s disease is characterized by two main neuropathological hallmarks: extracellular plaques of amyloid-β (Aβ) protein and intracellular aggregates of tau protein. Although tau is normally a soluble monomer that bind microtubules, in disease it forms insoluble, hyperphosph...

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Bibliographic Details
Main Authors: Tirth K. Patel, LeMoyne Habimana-Griffin, Xuefeng Gao, Baogang Xu, Samuel Achilefu, Kari Alitalo, Celia A. McKee, Patrick W. Sheehan, Erik S. Musiek, Chengjie Xiong, Dean Coble, David M. Holtzman
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Tau
Tauopathy
Neurodegeneration
Dural lymphatic system
Glymphatic system
Online Access:http://link.springer.com/article/10.1186/s13024-019-0312-x

Internet

http://link.springer.com/article/10.1186/s13024-019-0312-x

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