Design, synthesis and pharmacological evaluation of some pyrazolopyrimidin-6(7H)-ones and tricyclic 8-oxo-dihydrooxazolopyrazolopyrimidin-9-ium chloride derivatives

In the present study, some pyrazolopyrimidin-6(7H)-ones and tricyclic 8-oxo-dihydrooxazolopyrazolopyrimidin-9-ium chloride derivatives were synthesized and tested for anti-inflammatory and analgesic activity and assessment of acute ulcerogenic propensity as compared to the standard drug indomethacin...

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Main Authors:	Akanksha Kulshrestha, Nirupam Das, Anupam G. Banerjee, Sushant K. Shrivastava
Format:	Article
Language:	English
Published:	Elsevier 2017-05-01
Series:	Arabian Journal of Chemistry
Subjects:	Pyrazolopyrimidine Dihydrooxazolo Analgesic Anti-inflammatory Ulcer Synthesis
Online Access:	http://www.sciencedirect.com/science/article/pii/S1878535214000665

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record_format	Article
spelling	doaj-dc074e24cdf34b44a446004255c87a3c2020-11-24T23:23:02ZengElsevierArabian Journal of Chemistry1878-53522017-05-0110S2S3614S362110.1016/j.arabjc.2014.03.012Design, synthesis and pharmacological evaluation of some pyrazolopyrimidin-6(7H)-ones and tricyclic 8-oxo-dihydrooxazolopyrazolopyrimidin-9-ium chloride derivativesAkanksha KulshresthaNirupam DasAnupam G. BanerjeeSushant K. ShrivastavaIn the present study, some pyrazolopyrimidin-6(7H)-ones and tricyclic 8-oxo-dihydrooxazolopyrazolopyrimidin-9-ium chloride derivatives were synthesized and tested for anti-inflammatory and analgesic activity and assessment of acute ulcerogenic propensity as compared to the standard drug indomethacin. Some of the compounds (2c–2e; 3c–3e) showed appreciable anti-inflammatory–analgesic activity at the evaluated equimolar dose with lower ulcerogenic profile when compared with the standard. Compounds containing fused dihydrooxazolo ring (3e) system were found to be more active than their corresponding congener pyrazolopyrimidine.http://www.sciencedirect.com/science/article/pii/S1878535214000665PyrazolopyrimidineDihydrooxazoloAnalgesicAnti-inflammatoryUlcerSynthesis
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Akanksha Kulshrestha Nirupam Das Anupam G. Banerjee Sushant K. Shrivastava
spellingShingle	Akanksha Kulshrestha Nirupam Das Anupam G. Banerjee Sushant K. Shrivastava Design, synthesis and pharmacological evaluation of some pyrazolopyrimidin-6(7H)-ones and tricyclic 8-oxo-dihydrooxazolopyrazolopyrimidin-9-ium chloride derivatives Arabian Journal of Chemistry Pyrazolopyrimidine Dihydrooxazolo Analgesic Anti-inflammatory Ulcer Synthesis
author_facet	Akanksha Kulshrestha Nirupam Das Anupam G. Banerjee Sushant K. Shrivastava
author_sort	Akanksha Kulshrestha
title	Design, synthesis and pharmacological evaluation of some pyrazolopyrimidin-6(7H)-ones and tricyclic 8-oxo-dihydrooxazolopyrazolopyrimidin-9-ium chloride derivatives
title_short	Design, synthesis and pharmacological evaluation of some pyrazolopyrimidin-6(7H)-ones and tricyclic 8-oxo-dihydrooxazolopyrazolopyrimidin-9-ium chloride derivatives
title_full	Design, synthesis and pharmacological evaluation of some pyrazolopyrimidin-6(7H)-ones and tricyclic 8-oxo-dihydrooxazolopyrazolopyrimidin-9-ium chloride derivatives
title_fullStr	Design, synthesis and pharmacological evaluation of some pyrazolopyrimidin-6(7H)-ones and tricyclic 8-oxo-dihydrooxazolopyrazolopyrimidin-9-ium chloride derivatives
title_full_unstemmed	Design, synthesis and pharmacological evaluation of some pyrazolopyrimidin-6(7H)-ones and tricyclic 8-oxo-dihydrooxazolopyrazolopyrimidin-9-ium chloride derivatives
title_sort	design, synthesis and pharmacological evaluation of some pyrazolopyrimidin-6(7h)-ones and tricyclic 8-oxo-dihydrooxazolopyrazolopyrimidin-9-ium chloride derivatives
publisher	Elsevier
series	Arabian Journal of Chemistry
issn	1878-5352
publishDate	2017-05-01
description	In the present study, some pyrazolopyrimidin-6(7H)-ones and tricyclic 8-oxo-dihydrooxazolopyrazolopyrimidin-9-ium chloride derivatives were synthesized and tested for anti-inflammatory and analgesic activity and assessment of acute ulcerogenic propensity as compared to the standard drug indomethacin. Some of the compounds (2c–2e; 3c–3e) showed appreciable anti-inflammatory–analgesic activity at the evaluated equimolar dose with lower ulcerogenic profile when compared with the standard. Compounds containing fused dihydrooxazolo ring (3e) system were found to be more active than their corresponding congener pyrazolopyrimidine.
topic	Pyrazolopyrimidine Dihydrooxazolo Analgesic Anti-inflammatory Ulcer Synthesis
url	http://www.sciencedirect.com/science/article/pii/S1878535214000665
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Design, synthesis and pharmacological evaluation of some pyrazolopyrimidin-6(7H)-ones and tricyclic 8-oxo-dihydrooxazolopyrazolopyrimidin-9-ium chloride derivatives

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