Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts.
Chondrocytes proliferate and mature into hypertrophic chondrocytes. Vascular invasion into the cartilage occurs in the terminal hypertrophic chondrocyte layer, and terminal hypertrophic chondrocytes die by apoptosis or transdifferentiate into osteoblasts. Runx2 is essential for osteoblast differenti...
Main Authors: | Xin Qin, Qing Jiang, Kenichi Nagano, Takeshi Moriishi, Toshihiro Miyazaki, Hisato Komori, Kosei Ito, Klaus von der Mark, Chiharu Sakane, Hitomi Kaneko, Toshihisa Komori |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2020-11-01
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Series: | PLoS Genetics |
Online Access: | https://doi.org/10.1371/journal.pgen.1009169 |
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