Integrin-Mediated Adhesion and Chemoresistance of Acute Lymphoblastic Leukemia Cells Residing in the Bone Marrow or the Central Nervous System

Integrin-Mediated Adhesion and Chemoresistance of Acute Lymphoblastic Leukemia Cells Residing in the Bone Marrow or the Central Nervous System

Acute Lymphoblastic Leukemia (ALL) is the most common cancer in childhood. Despite a significantly improved prognosis over the last decade with a 5-years survival rate of ~90%, treatment-related morbidity remains substantial and relapse occurs in 10–15% of patients (1). The most common site of relap...

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Bibliographic Details
Main Authors: Bibi Fatima Syed Shah Scharff, Signe Modvig, Hanne Vibeke Marquart, Claus Christensen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Oncology
Subjects:
acute lymphoblastic leukemia
integrins
chemoresistance
CNS
bone marrow
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00775/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00775/full

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