[PROVISIONAL] The differential effects of the methylenetetrahydrofolate reductase polymorphisms (C677T and A1298C) on hematological malignancies among Latinos: a meta-analysis

• Main Authors: Samanta Celeste Garcia-Hernandez, Perla Meneses-Sanchez, Leonardo Martin Porchia, Enrique Torres-Rasgado, Ricardo Pérez-Fuentes, Martha Elba Gonzalez-Mejia
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Genética
• Series: Genetics and Molecular Biology
• Subjects: MTHFR; protective factor; Latin America; Leukemia
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019005022102&lng=en&tlng=en

Abstract Our objective was to determine the association between the methylenetetrahydrofolate reductase polymorphisms (C677T and A1298C) and the risk of developing acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), acute myeloid leukemia (AML), and multiple myelomas (MM) for Latinos. PubMed, SCOPUS, EBSCO, LILACS, and other Latin-specific databases were searched for case-control studies that investigated the association between these polymorphisms and hematologic malignancies until November 2017. Genotype distributions were extracted and either Fixed-Effects or Random-Effects models were used to calculate the pooled crude odds ratios (ORs) for the heterozygous, homozygous, dominant, recessive, and allelic genetic models. No publication bias was detected by the Begg-Mazumdar's test and Egger's test. From 290 publications, we identified 15 studies for C677T polymorphism and 13 studies for the A1298C polymorphism. We observed a significant decrease in risk for the C677T polymorphism (OR range=0.54-0.75, p<0.01) and a significant increase risk for the A1298C polymorphism (OR range=1.28-2.52, p<0.05) for developing ALL for all genetic models. No associations were determined for CML, AML, or MM for either polymorphism. This meta-analysis demonstrates that the A1298C polymorphism was associated with an increased risk of developing ALL, whereas the C677T polymorphism was associated with a decrease risk (protective factor) for the Latino population.