Spotlight on USP4: Structure, Function, and Regulation

Spotlight on USP4: Structure, Function, and Regulation

The deubiquitinating enzyme (DUB)–mediated cleavage of ubiquitin plays a critical role in balancing protein synthesis and degradation. Ubiquitin-specific protease 4 (USP4), a member of the largest subfamily of cysteine protease DUBs, removes monoubiquitinated and polyubiquitinated chains from its ta...

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Bibliographic Details
Main Authors: Binbin Hu, Dingyue Zhang, Kejia Zhao, Yang Wang, Lijiao Pei, Qianmei Fu, Xuelei Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
USP4
deubiquitinase
NF-κB
cancer
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.595159/full

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