Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity

Human adenoviruses are large (150 MDa) nonenveloped double-stranded DNA (dsDNA) viruses that cause acute respiratory, gastrointestinal and ocular infections. Despite these disease associations, adenovirus has aided basic and clinical research efforts through studies of its association with cells and...

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Main Authors:	Glen R. Nemerow, Phoebe L. Stewart
Format:	Article
Language:	English
Published:	MDPI AG 2016-12-01
Series:	Viruses
Subjects:	adenovirus AFM capsid disassembly integrins defensins cryoelectron microscopy antibody neutralization nuclear pore dynein hexon penton base protein VI ts1 cysteine protease nuclear porins microtubules adenovirus receptors
Online Access:	http://www.mdpi.com/1999-4915/8/12/337

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spelling	doaj-dc28b54156804d3b90817781f9ce9ea22020-11-25T01:02:53ZengMDPI AGViruses1999-49152016-12-0181233710.3390/v8120337v8120337Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host ImmunityGlen R. Nemerow0Phoebe L. Stewart1Department of Immunology and Microbial Science the Scripps Research Institute, La Jolla, CA 92037, USADepartment of Pharmacology and Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, Cleveland, OH 44106, USAHuman adenoviruses are large (150 MDa) nonenveloped double-stranded DNA (dsDNA) viruses that cause acute respiratory, gastrointestinal and ocular infections. Despite these disease associations, adenovirus has aided basic and clinical research efforts through studies of its association with cells and as a target of host antiviral responses. This review highlights the knowledge of adenovirus disassembly and nuclear transport gleaned from structural, biophysical and functional analyses of adenovirus interactions with soluble and membrane-associated host molecules.http://www.mdpi.com/1999-4915/8/12/337adenovirusAFMcapsid disassemblyintegrinsdefensinscryoelectron microscopyantibodyneutralizationnuclear poredyneinhexonpenton baseprotein VIts1cysteine proteasenuclear porinsmicrotubulesadenovirus receptors
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Glen R. Nemerow Phoebe L. Stewart
spellingShingle	Glen R. Nemerow Phoebe L. Stewart Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity Viruses adenovirus AFM capsid disassembly integrins defensins cryoelectron microscopy antibody neutralization nuclear pore dynein hexon penton base protein VI ts1 cysteine protease nuclear porins microtubules adenovirus receptors
author_facet	Glen R. Nemerow Phoebe L. Stewart
author_sort	Glen R. Nemerow
title	Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity
title_short	Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity
title_full	Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity
title_fullStr	Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity
title_full_unstemmed	Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity
title_sort	insights into adenovirus uncoating from interactions with integrins and mediators of host immunity
publisher	MDPI AG
series	Viruses
issn	1999-4915
publishDate	2016-12-01
description	Human adenoviruses are large (150 MDa) nonenveloped double-stranded DNA (dsDNA) viruses that cause acute respiratory, gastrointestinal and ocular infections. Despite these disease associations, adenovirus has aided basic and clinical research efforts through studies of its association with cells and as a target of host antiviral responses. This review highlights the knowledge of adenovirus disassembly and nuclear transport gleaned from structural, biophysical and functional analyses of adenovirus interactions with soluble and membrane-associated host molecules.
topic	adenovirus AFM capsid disassembly integrins defensins cryoelectron microscopy antibody neutralization nuclear pore dynein hexon penton base protein VI ts1 cysteine protease nuclear porins microtubules adenovirus receptors
url	http://www.mdpi.com/1999-4915/8/12/337
work_keys_str_mv	AT glenrnemerow insightsintoadenovirusuncoatingfrominteractionswithintegrinsandmediatorsofhostimmunity AT phoebelstewart insightsintoadenovirusuncoatingfrominteractionswithintegrinsandmediatorsofhostimmunity
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Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity

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