Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity
Human adenoviruses are large (150 MDa) nonenveloped double-stranded DNA (dsDNA) viruses that cause acute respiratory, gastrointestinal and ocular infections. Despite these disease associations, adenovirus has aided basic and clinical research efforts through studies of its association with cells and...
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doaj-dc28b54156804d3b90817781f9ce9ea22020-11-25T01:02:53ZengMDPI AGViruses1999-49152016-12-0181233710.3390/v8120337v8120337Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host ImmunityGlen R. Nemerow0Phoebe L. Stewart1Department of Immunology and Microbial Science the Scripps Research Institute, La Jolla, CA 92037, USADepartment of Pharmacology and Cleveland Center for Membrane and Structural Biology, Case Western Reserve University, Cleveland, OH 44106, USAHuman adenoviruses are large (150 MDa) nonenveloped double-stranded DNA (dsDNA) viruses that cause acute respiratory, gastrointestinal and ocular infections. Despite these disease associations, adenovirus has aided basic and clinical research efforts through studies of its association with cells and as a target of host antiviral responses. This review highlights the knowledge of adenovirus disassembly and nuclear transport gleaned from structural, biophysical and functional analyses of adenovirus interactions with soluble and membrane-associated host molecules.http://www.mdpi.com/1999-4915/8/12/337adenovirusAFMcapsid disassemblyintegrinsdefensinscryoelectron microscopyantibodyneutralizationnuclear poredyneinhexonpenton baseprotein VIts1cysteine proteasenuclear porinsmicrotubulesadenovirus receptors |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Glen R. Nemerow Phoebe L. Stewart |
spellingShingle |
Glen R. Nemerow Phoebe L. Stewart Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity Viruses adenovirus AFM capsid disassembly integrins defensins cryoelectron microscopy antibody neutralization nuclear pore dynein hexon penton base protein VI ts1 cysteine protease nuclear porins microtubules adenovirus receptors |
author_facet |
Glen R. Nemerow Phoebe L. Stewart |
author_sort |
Glen R. Nemerow |
title |
Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity |
title_short |
Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity |
title_full |
Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity |
title_fullStr |
Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity |
title_full_unstemmed |
Insights into Adenovirus Uncoating from Interactions with Integrins and Mediators of Host Immunity |
title_sort |
insights into adenovirus uncoating from interactions with integrins and mediators of host immunity |
publisher |
MDPI AG |
series |
Viruses |
issn |
1999-4915 |
publishDate |
2016-12-01 |
description |
Human adenoviruses are large (150 MDa) nonenveloped double-stranded DNA (dsDNA) viruses that cause acute respiratory, gastrointestinal and ocular infections. Despite these disease associations, adenovirus has aided basic and clinical research efforts through studies of its association with cells and as a target of host antiviral responses. This review highlights the knowledge of adenovirus disassembly and nuclear transport gleaned from structural, biophysical and functional analyses of adenovirus interactions with soluble and membrane-associated host molecules. |
topic |
adenovirus AFM capsid disassembly integrins defensins cryoelectron microscopy antibody neutralization nuclear pore dynein hexon penton base protein VI ts1 cysteine protease nuclear porins microtubules adenovirus receptors |
url |
http://www.mdpi.com/1999-4915/8/12/337 |
work_keys_str_mv |
AT glenrnemerow insightsintoadenovirusuncoatingfrominteractionswithintegrinsandmediatorsofhostimmunity AT phoebelstewart insightsintoadenovirusuncoatingfrominteractionswithintegrinsandmediatorsofhostimmunity |
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