Effects of lipid-lowing anticoagulant antihypertensive drugs combined with ginkgo capsule on endothelial injury and plaque stability in patients with carotid atherosclerosis
Objective: To investigate the effects of lipid-lowing anticoagulant antihypertensive drugs combined with ginkgo capsule on endothelial injury and plaque stability in patients with carotid atherosclerosis. Methods: A total of 114 patients with carotid atherosclerosis who were treated in Songzi Peo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2018-03-01
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| Series: | Journal of Hainan Medical University |
| Subjects: | |
| Online Access: | http://www.hnykdxxb.com/PDF/201803/03.pdf |
| Summary: | Objective: To investigate the effects of lipid-lowing anticoagulant antihypertensive drugs
combined with ginkgo capsule on endothelial injury and plaque stability in patients with
carotid atherosclerosis. Methods: A total of 114 patients with carotid atherosclerosis who were
treated in Songzi People's Hospital between April 2016 and January 2017 were collected and
divided into control group (n=57) and ginkgo capsule group (n=57) by random number table.
Control group received conventional lipid-lowing anticoagulant antihypertensive drug therapy
and ginkgo capsule group received lipid-lowing anticoagulant antihypertensive drugs combined
with ginkgo capsule therapy. The differences in endothelial injury and plaque stability
were compared between the two groups before and after treatment. Results: There was no
statistically significant difference in serum levels of endothelial function indexes and plaque
stability-related indexes between the two groups before treatment. After 1 month of treatment
and after 6 months of treatment, serum endothelial injury indexes sVCAM-1, vWF and ET-1
levels of ginkgo capsule group were lower than those of control group at corresponding
points in time whereas NO and 6-Reto-PGF1α levels were higher than those of control group
at corresponding points in time; serum plaque stability-related indexes LEP, RETN, Hcy,
PTX3 and Lp-PLA2 levels were lower than those of control group at corresponding points in
time whereas APN levels were higher than those of control group at corresponding points in
time. Conclusions: Lipid-lowing anticoagulant antihypertensive drugs combined with ginkgo
capsule therapy can effectively protect the vascular endothelial function and stabilize the
atherosclerotic plaque in patients with carotid atherosclerosis. |
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| ISSN: | 1007-1237 1007-1237 |