Effects of lipid-lowing anticoagulant antihypertensive drugs combined with ginkgo capsule on endothelial injury and plaque stability in patients with carotid atherosclerosis

• Main Authors: Shi-Nian Zou, Zu-Bin Wang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2018-03-01
• Series: Journal of Hainan Medical University
• Subjects: Carotid atherosclerosis; Ginkgo capsule; Endothelial injury; Plaque stability
• Online Access: http://www.hnykdxxb.com/PDF/201803/03.pdf

Objective: To investigate the effects of lipid-lowing anticoagulant antihypertensive drugs combined with ginkgo capsule on endothelial injury and plaque stability in patients with carotid atherosclerosis. Methods: A total of 114 patients with carotid atherosclerosis who were treated in Songzi People's Hospital between April 2016 and January 2017 were collected and divided into control group (n=57) and ginkgo capsule group (n=57) by random number table. Control group received conventional lipid-lowing anticoagulant antihypertensive drug therapy and ginkgo capsule group received lipid-lowing anticoagulant antihypertensive drugs combined with ginkgo capsule therapy. The differences in endothelial injury and plaque stability were compared between the two groups before and after treatment. Results: There was no statistically significant difference in serum levels of endothelial function indexes and plaque stability-related indexes between the two groups before treatment. After 1 month of treatment and after 6 months of treatment, serum endothelial injury indexes sVCAM-1, vWF and ET-1 levels of ginkgo capsule group were lower than those of control group at corresponding points in time whereas NO and 6-Reto-PGF1α levels were higher than those of control group at corresponding points in time; serum plaque stability-related indexes LEP, RETN, Hcy, PTX3 and Lp-PLA2 levels were lower than those of control group at corresponding points in time whereas APN levels were higher than those of control group at corresponding points in time. Conclusions: Lipid-lowing anticoagulant antihypertensive drugs combined with ginkgo capsule therapy can effectively protect the vascular endothelial function and stabilize the atherosclerotic plaque in patients with carotid atherosclerosis.