Decreased Expression and Induced Nucleocytoplasmic Translocation of Pancreatic and Duodenal Homeobox 1 in INS-1 Cells Exposed to High Glucose and Palmitate

Decreased Expression and Induced Nucleocytoplasmic Translocation of Pancreatic and Duodenal Homeobox 1 in INS-1 Cells Exposed to High Glucose and Palmitate

BackgroundType 2 diabetes mellitus (T2DM) is often accompanied by increased levels of circulating fatty acid. Elevations in fatty acids and glucose for prolonged periods of time have been suggested to cause progressive dysfunction or apoptosis of pancreatic beta cells in T2DM. However, the precise m...

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Bibliographic Details
Main Authors: Gyeong Ryul Ryu, Jun Mo Yoo, Esder Lee, Seung-Hyun Ko, Yu-Bae Ahn, Ki-Ho Song
Format: Article
Language:English
Published: Korean Diabetes Association 2011-02-01
Series:Diabetes & Metabolism Journal
Subjects:
Fatty acid
High glucose
Insulin
Oxidative stress
Palmitate
Pancreatic beta cell
Pdx1
Online Access:http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-35-65.pdf

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