The impact of Recipient and Donor Characteristics on Kidney Transplant Graft Survival

Introduction Many factors determine the outcomes of renal transplant, including characteristics of both donors and recipients. Antihuman leukocyte antigen donor-specific antibodies are strongly linked to antibody-mediated rejection and late allograft loss. Aim The aim was to determine the effect of...

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Main Authors: Azza A I. Elmenyawia, Ashraf Donia, Tarek T Ahmed
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Series:Journal of Medicine in Scientific Research
Subjects:
Online Access:http://www.jmsr.eg.net/article.asp?issn=2537-091X;year=2021;volume=4;issue=1;spage=11;epage=25;aulast=I.
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spelling doaj-dc3ad9bf6ed740bcad30238d4157c3722021-06-02T09:49:34ZengWolters Kluwer Medknow PublicationsJournal of Medicine in Scientific Research2537-091X2537-09282021-01-0141112510.4103/JMISR.JMISR_80_20The impact of Recipient and Donor Characteristics on Kidney Transplant Graft SurvivalAzza A I. ElmenyawiaAshraf DoniaTarek T AhmedIntroduction Many factors determine the outcomes of renal transplant, including characteristics of both donors and recipients. Antihuman leukocyte antigen donor-specific antibodies are strongly linked to antibody-mediated rejection and late allograft loss. Aim The aim was to determine the effect of recipient and donor characteristics on kidney transplant graft survival, with special stress on panel-reactive antibodies. Participants and methods This study included 168 adult recipient and donor couples. The authors analyzed data of kidney transplants performed between the years of 2008 and 2018 at National Institute of Urology and Nephrology. Results The authors found a significant increase in renal failure in recipients transplanted with unrelated donor kidney and in positive hepatitis C virus antibodies (HCV Abs) recipients (P = 0.002 and 0.001, respectively) and renal complications (P ≤ 0.001). There was also a significant increase in panel-reactive antibody-positive recipients to get renal complications (P = 0.03). There was a significant increase in renal failure with old-aged recipients (P = 0.008) and with increased duration of transplant (P = 0.003). By multivariate regression, the authors deduced that young age decreases graft loss risk (hazard ratio (HR): 0.88; 95% confidence interval (95% CI): 0.79–0.97; P = 0.017). Recipients of unrelated donor graft and HCV infection were associated with higher hazard ratio graft loss (HR: 13.56; 95% CI: 2.58–71.22; P = 0.002, and HR: 7.96; 95% CI: 1.04–60.44; P = 0.45). Unrelated donors graft were associated with 4 times higher hazard ratio renal complication (HR: 4.18; 95% CI: 2.01–8.72; P = 0.003). HCV infection increases risk three times (HR: 3.24; 95% CI: 1.31–7.99; P = 0.010). Unrelated donor was a significant independent predictor for recipient graft loss risk in a period of more than 5 years after transplantation. Conclusion The authors concluded that recipient and donor characteristics have important roles on kidney transplant graft survival and also on renal complications.http://www.jmsr.eg.net/article.asp?issn=2537-091X;year=2021;volume=4;issue=1;spage=11;epage=25;aulast=I.a recipient and donor characteristicskidney transplant and graft survivalrenal complications
collection DOAJ
language English
format Article
sources DOAJ
author Azza A I. Elmenyawia
Ashraf Donia
Tarek T Ahmed
spellingShingle Azza A I. Elmenyawia
Ashraf Donia
Tarek T Ahmed
The impact of Recipient and Donor Characteristics on Kidney Transplant Graft Survival
Journal of Medicine in Scientific Research
a recipient and donor characteristics
kidney transplant and graft survival
renal complications
author_facet Azza A I. Elmenyawia
Ashraf Donia
Tarek T Ahmed
author_sort Azza A I. Elmenyawia
title The impact of Recipient and Donor Characteristics on Kidney Transplant Graft Survival
title_short The impact of Recipient and Donor Characteristics on Kidney Transplant Graft Survival
title_full The impact of Recipient and Donor Characteristics on Kidney Transplant Graft Survival
title_fullStr The impact of Recipient and Donor Characteristics on Kidney Transplant Graft Survival
title_full_unstemmed The impact of Recipient and Donor Characteristics on Kidney Transplant Graft Survival
title_sort impact of recipient and donor characteristics on kidney transplant graft survival
publisher Wolters Kluwer Medknow Publications
series Journal of Medicine in Scientific Research
issn 2537-091X
2537-0928
publishDate 2021-01-01
description Introduction Many factors determine the outcomes of renal transplant, including characteristics of both donors and recipients. Antihuman leukocyte antigen donor-specific antibodies are strongly linked to antibody-mediated rejection and late allograft loss. Aim The aim was to determine the effect of recipient and donor characteristics on kidney transplant graft survival, with special stress on panel-reactive antibodies. Participants and methods This study included 168 adult recipient and donor couples. The authors analyzed data of kidney transplants performed between the years of 2008 and 2018 at National Institute of Urology and Nephrology. Results The authors found a significant increase in renal failure in recipients transplanted with unrelated donor kidney and in positive hepatitis C virus antibodies (HCV Abs) recipients (P = 0.002 and 0.001, respectively) and renal complications (P ≤ 0.001). There was also a significant increase in panel-reactive antibody-positive recipients to get renal complications (P = 0.03). There was a significant increase in renal failure with old-aged recipients (P = 0.008) and with increased duration of transplant (P = 0.003). By multivariate regression, the authors deduced that young age decreases graft loss risk (hazard ratio (HR): 0.88; 95% confidence interval (95% CI): 0.79–0.97; P = 0.017). Recipients of unrelated donor graft and HCV infection were associated with higher hazard ratio graft loss (HR: 13.56; 95% CI: 2.58–71.22; P = 0.002, and HR: 7.96; 95% CI: 1.04–60.44; P = 0.45). Unrelated donors graft were associated with 4 times higher hazard ratio renal complication (HR: 4.18; 95% CI: 2.01–8.72; P = 0.003). HCV infection increases risk three times (HR: 3.24; 95% CI: 1.31–7.99; P = 0.010). Unrelated donor was a significant independent predictor for recipient graft loss risk in a period of more than 5 years after transplantation. Conclusion The authors concluded that recipient and donor characteristics have important roles on kidney transplant graft survival and also on renal complications.
topic a recipient and donor characteristics
kidney transplant and graft survival
renal complications
url http://www.jmsr.eg.net/article.asp?issn=2537-091X;year=2021;volume=4;issue=1;spage=11;epage=25;aulast=I.
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