Investigating the Role of Indoleamine 2,3-Dioxygenase in Acute Myeloid Leukemia: A Systematic Review

Investigating the Role of Indoleamine 2,3-Dioxygenase in Acute Myeloid Leukemia: A Systematic Review

Background: The immunomodulatory enzyme, indoleamine 2,3-dioxygenase (IDO) facilitates tryptophan catabolism at the rate-limiting step of the kynurenine (Kyn) pathway. IDO expression and elevations in Kyn metabolites are associated with immunosuppressive tumor microenvironment including T cell proli...

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Bibliographic Details
Main Authors:	Georgia Wells, Paul T. Kennedy, Lekh N. Dahal
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-03-01
Series:	Frontiers in Immunology
Subjects:	acute myeliod leukemia regulatory T cells indoleamine 2,3-dioxygenase prognosis 1-Methyltryptophan
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.651687/full

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