Intravenous administration of tranexamic acid in total hip arthroplasty does not change the blood coagulopathy: a prospective thrombelastography analysis
Objective: Despite the wide use of tranexamic acid (TXA) in the perioperative period of total hip arthroplasty (THA), whether the hemostatic state changes after the application of intravenous (IV)-TXA are still unknown. The aim of this study was to investigate whether IV administration of TXA change...
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2020-09-01
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Series: | Journal of Orthopaedic Surgery |
Online Access: | https://doi.org/10.1177/2309499020959516 |
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doaj-dc475f85ab124771953598ba3f7aa5e02020-11-25T03:22:01ZengSAGE PublishingJournal of Orthopaedic Surgery2309-49902020-09-012810.1177/2309499020959516Intravenous administration of tranexamic acid in total hip arthroplasty does not change the blood coagulopathy: a prospective thrombelastography analysisXing-chen Zhang0Ma-ji Sun1Sheng Pan2Min Rui3Feng-chao Zhao4Guo-chun Zha5Yong Pang6Xin Zheng7Kai-jin Guo8 Department of Orthopaedics, , Xuzhou, China Department of Orthopaedics, , Xuzhou, China Department of Orthopaedics, , Xuzhou, China Department of Orthopaedics, Jiangsu Jiangyin People’s Hospital, Jiangyin, China Department of Orthopaedics, , Hangzhou, China Department of Orthopaedics, , Xuzhou, China Department of Orthopaedics, , Xuzhou, China Department of Orthopaedics, , Xuzhou, China Department of Orthopaedics, , Xuzhou, ChinaObjective: Despite the wide use of tranexamic acid (TXA) in the perioperative period of total hip arthroplasty (THA), whether the hemostatic state changes after the application of intravenous (IV)-TXA are still unknown. The aim of this study was to investigate whether IV administration of TXA changes the blood coagulation following primary THA via thrombelastography (TEG) analysis and conventional laboratory tests. Methods: A total of 174 patients who underwent primary THA from September 2016 to July 2018 were selected. They were randomly divided into two groups, 86 patients with IV administration of 15 mg/kg TXA and 88 controls without TXA usage. Demographic data, TEG paremeters, d -dimer levels, fibrin degradation products, hemoglobin, hematocrit concentration, platelet, transfusion rates, perioperative blood loss, and the occurrence of deep vein thrombosis were collected. TEG and conventional laboratory tests were performed the day before operation, the first day after operation, and seventh day after operation. Results: There were no differences with regard to TEG or conventional laboratory tests between the two groups ( p > 0.05). The total blood loss and drain blood loss in the TXA group were significantly lower than those in the control group ( p < 0.05). The transfusion rates and the volume of blood transfusion of the control group were higher than those of the TXA group ( p < 0.05). Conclusion: The administration of IV-TXA resulted in a significant reduction in total blood loss, transfusion volumes, and transfusion rates without the increase of thromboembolic complications. Moreover, it was confirmed that TXA would not change the coagulation via the TEG analysis.https://doi.org/10.1177/2309499020959516 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xing-chen Zhang Ma-ji Sun Sheng Pan Min Rui Feng-chao Zhao Guo-chun Zha Yong Pang Xin Zheng Kai-jin Guo |
spellingShingle |
Xing-chen Zhang Ma-ji Sun Sheng Pan Min Rui Feng-chao Zhao Guo-chun Zha Yong Pang Xin Zheng Kai-jin Guo Intravenous administration of tranexamic acid in total hip arthroplasty does not change the blood coagulopathy: a prospective thrombelastography analysis Journal of Orthopaedic Surgery |
author_facet |
Xing-chen Zhang Ma-ji Sun Sheng Pan Min Rui Feng-chao Zhao Guo-chun Zha Yong Pang Xin Zheng Kai-jin Guo |
author_sort |
Xing-chen Zhang |
title |
Intravenous administration of tranexamic acid in total hip arthroplasty does not change the blood coagulopathy: a prospective thrombelastography analysis |
title_short |
Intravenous administration of tranexamic acid in total hip arthroplasty does not change the blood coagulopathy: a prospective thrombelastography analysis |
title_full |
Intravenous administration of tranexamic acid in total hip arthroplasty does not change the blood coagulopathy: a prospective thrombelastography analysis |
title_fullStr |
Intravenous administration of tranexamic acid in total hip arthroplasty does not change the blood coagulopathy: a prospective thrombelastography analysis |
title_full_unstemmed |
Intravenous administration of tranexamic acid in total hip arthroplasty does not change the blood coagulopathy: a prospective thrombelastography analysis |
title_sort |
intravenous administration of tranexamic acid in total hip arthroplasty does not change the blood coagulopathy: a prospective thrombelastography analysis |
publisher |
SAGE Publishing |
series |
Journal of Orthopaedic Surgery |
issn |
2309-4990 |
publishDate |
2020-09-01 |
description |
Objective: Despite the wide use of tranexamic acid (TXA) in the perioperative period of total hip arthroplasty (THA), whether the hemostatic state changes after the application of intravenous (IV)-TXA are still unknown. The aim of this study was to investigate whether IV administration of TXA changes the blood coagulation following primary THA via thrombelastography (TEG) analysis and conventional laboratory tests. Methods: A total of 174 patients who underwent primary THA from September 2016 to July 2018 were selected. They were randomly divided into two groups, 86 patients with IV administration of 15 mg/kg TXA and 88 controls without TXA usage. Demographic data, TEG paremeters, d -dimer levels, fibrin degradation products, hemoglobin, hematocrit concentration, platelet, transfusion rates, perioperative blood loss, and the occurrence of deep vein thrombosis were collected. TEG and conventional laboratory tests were performed the day before operation, the first day after operation, and seventh day after operation. Results: There were no differences with regard to TEG or conventional laboratory tests between the two groups ( p > 0.05). The total blood loss and drain blood loss in the TXA group were significantly lower than those in the control group ( p < 0.05). The transfusion rates and the volume of blood transfusion of the control group were higher than those of the TXA group ( p < 0.05). Conclusion: The administration of IV-TXA resulted in a significant reduction in total blood loss, transfusion volumes, and transfusion rates without the increase of thromboembolic complications. Moreover, it was confirmed that TXA would not change the coagulation via the TEG analysis. |
url |
https://doi.org/10.1177/2309499020959516 |
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