Monitored anesthesia care (MAC) sedation: clinical utility of fospropofol
Eric A Harris, David A Lubarsky, Keith A CandiottiDepartment of Anesthesiology, Perioperative Management, and Pain Medicine, University of Miami/Miller School of MedicineAbstract: Fospropofol, a phosphorylated prodrug version of the popular induction agent propofol, is hydrolyzed in vivo to release...
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2009-12-01
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doaj-dc517530a36d4d6bbd3bab5558bfa6bb2020-11-24T22:41:56ZengDove Medical PressTherapeutics and Clinical Risk Management1176-63361178-203X2009-12-012009default949959Monitored anesthesia care (MAC) sedation: clinical utility of fospropofolEric A HarrisDavid A LubarskyKeith A CandiottiEric A Harris, David A Lubarsky, Keith A CandiottiDepartment of Anesthesiology, Perioperative Management, and Pain Medicine, University of Miami/Miller School of MedicineAbstract: Fospropofol, a phosphorylated prodrug version of the popular induction agent propofol, is hydrolyzed in vivo to release active propofol, formaldehyde, and phosphate. Pharmacodynamic studies show fospropofol provides clinically useful sedation and EEG/bispectral index suppression while causing significantly less respiratory depression than propofol. Pain at the injection site, a common complaint with propofol, was not reported with fospropofol; the major patient complaint was transitory perianal itching during the drug’s administration. Although many clinicians believe fospropofol can safely be given by a registered nurse, the FDA mandated that fospropofol, like propofol, must be used only in the presence of a trained anesthesia provider.Keywords: fospropofol, propofol, monitored anesthesia care http://www.dovepress.com/monitored-anesthesia-care-mac-sedation-clinical-utility-of-fospropofol-a3811 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eric A Harris David A Lubarsky Keith A Candiotti |
spellingShingle |
Eric A Harris David A Lubarsky Keith A Candiotti Monitored anesthesia care (MAC) sedation: clinical utility of fospropofol Therapeutics and Clinical Risk Management |
author_facet |
Eric A Harris David A Lubarsky Keith A Candiotti |
author_sort |
Eric A Harris |
title |
Monitored anesthesia care (MAC) sedation: clinical utility of fospropofol |
title_short |
Monitored anesthesia care (MAC) sedation: clinical utility of fospropofol |
title_full |
Monitored anesthesia care (MAC) sedation: clinical utility of fospropofol |
title_fullStr |
Monitored anesthesia care (MAC) sedation: clinical utility of fospropofol |
title_full_unstemmed |
Monitored anesthesia care (MAC) sedation: clinical utility of fospropofol |
title_sort |
monitored anesthesia care (mac) sedation: clinical utility of fospropofol |
publisher |
Dove Medical Press |
series |
Therapeutics and Clinical Risk Management |
issn |
1176-6336 1178-203X |
publishDate |
2009-12-01 |
description |
Eric A Harris, David A Lubarsky, Keith A CandiottiDepartment of Anesthesiology, Perioperative Management, and Pain Medicine, University of Miami/Miller School of MedicineAbstract: Fospropofol, a phosphorylated prodrug version of the popular induction agent propofol, is hydrolyzed in vivo to release active propofol, formaldehyde, and phosphate. Pharmacodynamic studies show fospropofol provides clinically useful sedation and EEG/bispectral index suppression while causing significantly less respiratory depression than propofol. Pain at the injection site, a common complaint with propofol, was not reported with fospropofol; the major patient complaint was transitory perianal itching during the drug’s administration. Although many clinicians believe fospropofol can safely be given by a registered nurse, the FDA mandated that fospropofol, like propofol, must be used only in the presence of a trained anesthesia provider.Keywords: fospropofol, propofol, monitored anesthesia care |
url |
http://www.dovepress.com/monitored-anesthesia-care-mac-sedation-clinical-utility-of-fospropofol-a3811 |
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