Relationship between Prooxidant-Antioxidant Balance and Severity of Coronary Artery Disease in Patients of Imam Khomeini Hospital of Tehran, Iran
The balance between reactive oxygen species production and antioxidant activity has an important role in oxidative stress associated diseases including coronary artery disease. In this study, the prooxidant-antioxidant balance (PAB) and its correlations with serum lipid levels, uric acid levels, an...
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Tehran University of Medical Sciences
2014-02-01
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doaj-dc52c922fef743bf994d8cb57127c1672020-11-25T03:23:24ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942014-02-015224798Relationship between Prooxidant-Antioxidant Balance and Severity of Coronary Artery Disease in Patients of Imam Khomeini Hospital of Tehran, IranFariba Nabatchican0Nahid Einollahi1Ali Kazemi Khaledi2Department of Clinical Laboratory Sciences, Faculty of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.Department of Clinical Laboratory Sciences, Faculty of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.Department of Cardiology, Faculty of Medicine, Tehran University of Medical Sciences. Tehran, Iran. The balance between reactive oxygen species production and antioxidant activity has an important role in oxidative stress associated diseases including coronary artery disease. In this study, the prooxidant-antioxidant balance (PAB) and its correlations with serum lipid levels, uric acid levels, and severity of coronary artery involvement were examined. The aim of this study was to determine the diagnostic value of PAB as a predictor in coronary artery disease (CAD). Seventy two patients and 68 healthy subjects were selected. PAB was determined using standard solutions and ELISA. Triglyceride, total cholesterol, LDL-cholesterol, HDL-cholesterol and uric acid levels were measured by enzymatic method. Mean PAB was 66.4 ± 2.84 (HK units) in healthy people, 77.37 ± 33.51 (HK units) in patients with one vessel CAD, 63.76 ± 29.47 (HK units) in patients with two vessel CAD and 68.59 ± 24.51 (HK units) in patients with three or more vessel CAD. There was no significant difference between PAB values in different severity groups (P=0.41). PAB significantly and indirectly correlated with uric acid level in two vessels CAD. The study shows that PAB can be a predictor of CAD associated with other risk factors, but not alone. https://acta.tums.ac.ir/index.php/acta/article/view/4845Coronary artery diseaseLipid prooxidationAntioxidantOxidative stress |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fariba Nabatchican Nahid Einollahi Ali Kazemi Khaledi |
spellingShingle |
Fariba Nabatchican Nahid Einollahi Ali Kazemi Khaledi Relationship between Prooxidant-Antioxidant Balance and Severity of Coronary Artery Disease in Patients of Imam Khomeini Hospital of Tehran, Iran Acta Medica Iranica Coronary artery disease Lipid prooxidation Antioxidant Oxidative stress |
author_facet |
Fariba Nabatchican Nahid Einollahi Ali Kazemi Khaledi |
author_sort |
Fariba Nabatchican |
title |
Relationship between Prooxidant-Antioxidant Balance and Severity of Coronary Artery Disease in Patients of Imam Khomeini Hospital of Tehran, Iran |
title_short |
Relationship between Prooxidant-Antioxidant Balance and Severity of Coronary Artery Disease in Patients of Imam Khomeini Hospital of Tehran, Iran |
title_full |
Relationship between Prooxidant-Antioxidant Balance and Severity of Coronary Artery Disease in Patients of Imam Khomeini Hospital of Tehran, Iran |
title_fullStr |
Relationship between Prooxidant-Antioxidant Balance and Severity of Coronary Artery Disease in Patients of Imam Khomeini Hospital of Tehran, Iran |
title_full_unstemmed |
Relationship between Prooxidant-Antioxidant Balance and Severity of Coronary Artery Disease in Patients of Imam Khomeini Hospital of Tehran, Iran |
title_sort |
relationship between prooxidant-antioxidant balance and severity of coronary artery disease in patients of imam khomeini hospital of tehran, iran |
publisher |
Tehran University of Medical Sciences |
series |
Acta Medica Iranica |
issn |
0044-6025 1735-9694 |
publishDate |
2014-02-01 |
description |
The balance between reactive oxygen species production and antioxidant activity has an important role in oxidative stress associated diseases including coronary artery disease. In this study, the prooxidant-antioxidant balance (PAB) and its correlations with serum lipid levels, uric acid levels, and severity of coronary artery involvement were examined. The aim of this study was to determine the diagnostic value of PAB as a predictor in coronary artery disease (CAD). Seventy two patients and 68 healthy subjects were selected. PAB was determined using standard solutions and ELISA. Triglyceride, total cholesterol, LDL-cholesterol, HDL-cholesterol and uric acid levels were measured by enzymatic method. Mean PAB was 66.4 ± 2.84 (HK units) in healthy people, 77.37 ± 33.51 (HK units) in patients with one vessel CAD, 63.76 ± 29.47 (HK units) in patients with two vessel CAD and 68.59 ± 24.51 (HK units) in patients with three or more vessel CAD. There was no significant difference between PAB values in different severity groups (P=0.41). PAB significantly and indirectly correlated with uric acid level in two vessels CAD. The study shows that PAB can be a predictor of CAD associated with other risk factors, but not alone.
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topic |
Coronary artery disease Lipid prooxidation Antioxidant Oxidative stress |
url |
https://acta.tums.ac.ir/index.php/acta/article/view/4845 |
work_keys_str_mv |
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