Ionic Liquid as an Efficient Medium for the Synthesis of Quinoline Derivatives via α-Chymotrypsin-Catalyzed Friedländer Condensation

Ionic Liquid as an Efficient Medium for the Synthesis of Quinoline Derivatives via α-Chymotrypsin-Catalyzed Friedländer Condensation

An efficient, convenient, and eco-friendly biocatalytic approach was developed for the synthesis of quinoline derivatives via the α-chymotrypsin-catalyzed Friedländer reaction. Interestingly, α-chymotrypsin exhibited higher catalytic activity in an ionic liquid (IL) aqueous solution as compared to t...

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Bibliographic Details
Main Authors: Zhang-Gao Le, Meng Liang, Zhong-Sheng Chen, Sui-Hong Zhang, Zong-Bo Xie
Format: Article
Language:English
Published: MDPI AG 2017-05-01
Series:Molecules
Subjects:
Friedländer reaction
quinolines
α-chymotrypsin
ionic liquid
biocatalysis
promiscuity
Online Access:http://www.mdpi.com/1420-3049/22/5/762
Description
Summary:An efficient, convenient, and eco-friendly biocatalytic approach was developed for the synthesis of quinoline derivatives via the α-chymotrypsin-catalyzed Friedländer reaction. Interestingly, α-chymotrypsin exhibited higher catalytic activity in an ionic liquid (IL) aqueous solution as compared to that observed in our previous relevant study, which was conducted using an organic solvent, and a series of substrates gave similar excellent yields at lower reaction temperature and under reduced enzyme-loading conditions.
ISSN:1420-3049

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