Ionic Liquid as an Efficient Medium for the Synthesis of Quinoline Derivatives via α-Chymotrypsin-Catalyzed Friedländer Condensation

An efficient, convenient, and eco-friendly biocatalytic approach was developed for the synthesis of quinoline derivatives via the α-chymotrypsin-catalyzed Friedländer reaction. Interestingly, α-chymotrypsin exhibited higher catalytic activity in an ionic liquid (IL) aqueous solution as compared to t...

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Main Authors:	Zhang-Gao Le, Meng Liang, Zhong-Sheng Chen, Sui-Hong Zhang, Zong-Bo Xie
Format:	Article
Language:	English
Published:	MDPI AG 2017-05-01
Series:	Molecules
Subjects:	Friedländer reaction quinolines α-chymotrypsin ionic liquid biocatalysis promiscuity
Online Access:	http://www.mdpi.com/1420-3049/22/5/762

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spelling	doaj-dc54059a2c0946d0a8ad0fa34a3b9e632020-11-24T22:55:22ZengMDPI AGMolecules1420-30492017-05-0122576210.3390/molecules22050762molecules22050762Ionic Liquid as an Efficient Medium for the Synthesis of Quinoline Derivatives via α-Chymotrypsin-Catalyzed Friedländer CondensationZhang-Gao Le0Meng Liang1Zhong-Sheng Chen2Sui-Hong Zhang3Zong-Bo Xie4Jiangxi 2011 Joint Center for the Innovative Mass Spectrometry and Instrumentation, East China University of Technology, Nanchang 330013, ChinaSchool of Chemistry, Biology and Material Science, East China University of Technology, Nanchang 330013, ChinaSchool of Chemistry, Biology and Material Science, East China University of Technology, Nanchang 330013, ChinaSchool of Chemistry, Biology and Material Science, East China University of Technology, Nanchang 330013, ChinaJiangxi 2011 Joint Center for the Innovative Mass Spectrometry and Instrumentation, East China University of Technology, Nanchang 330013, ChinaAn efficient, convenient, and eco-friendly biocatalytic approach was developed for the synthesis of quinoline derivatives via the α-chymotrypsin-catalyzed Friedländer reaction. Interestingly, α-chymotrypsin exhibited higher catalytic activity in an ionic liquid (IL) aqueous solution as compared to that observed in our previous relevant study, which was conducted using an organic solvent, and a series of substrates gave similar excellent yields at lower reaction temperature and under reduced enzyme-loading conditions.http://www.mdpi.com/1420-3049/22/5/762Friedländer reactionquinolinesα-chymotrypsinionic liquidbiocatalysispromiscuity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Zhang-Gao Le Meng Liang Zhong-Sheng Chen Sui-Hong Zhang Zong-Bo Xie
spellingShingle	Zhang-Gao Le Meng Liang Zhong-Sheng Chen Sui-Hong Zhang Zong-Bo Xie Ionic Liquid as an Efficient Medium for the Synthesis of Quinoline Derivatives via α-Chymotrypsin-Catalyzed Friedländer Condensation Molecules Friedländer reaction quinolines α-chymotrypsin ionic liquid biocatalysis promiscuity
author_facet	Zhang-Gao Le Meng Liang Zhong-Sheng Chen Sui-Hong Zhang Zong-Bo Xie
author_sort	Zhang-Gao Le
title	Ionic Liquid as an Efficient Medium for the Synthesis of Quinoline Derivatives via α-Chymotrypsin-Catalyzed Friedländer Condensation
title_short	Ionic Liquid as an Efficient Medium for the Synthesis of Quinoline Derivatives via α-Chymotrypsin-Catalyzed Friedländer Condensation
title_full	Ionic Liquid as an Efficient Medium for the Synthesis of Quinoline Derivatives via α-Chymotrypsin-Catalyzed Friedländer Condensation
title_fullStr	Ionic Liquid as an Efficient Medium for the Synthesis of Quinoline Derivatives via α-Chymotrypsin-Catalyzed Friedländer Condensation
title_full_unstemmed	Ionic Liquid as an Efficient Medium for the Synthesis of Quinoline Derivatives via α-Chymotrypsin-Catalyzed Friedländer Condensation
title_sort	ionic liquid as an efficient medium for the synthesis of quinoline derivatives via α-chymotrypsin-catalyzed friedländer condensation
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2017-05-01
description	An efficient, convenient, and eco-friendly biocatalytic approach was developed for the synthesis of quinoline derivatives via the α-chymotrypsin-catalyzed Friedländer reaction. Interestingly, α-chymotrypsin exhibited higher catalytic activity in an ionic liquid (IL) aqueous solution as compared to that observed in our previous relevant study, which was conducted using an organic solvent, and a series of substrates gave similar excellent yields at lower reaction temperature and under reduced enzyme-loading conditions.
topic	Friedländer reaction quinolines α-chymotrypsin ionic liquid biocatalysis promiscuity
url	http://www.mdpi.com/1420-3049/22/5/762
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Ionic Liquid as an Efficient Medium for the Synthesis of Quinoline Derivatives via α-Chymotrypsin-Catalyzed Friedländer Condensation

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