Pemphigus vulgaris and amyotrophic lateral sclerosis
Pemphigus vulgaris (PV) is an autoimmune bullous and erosive mucocutaneous disease. Rarely, it occurs in patients with other autoimmune disease. The relation between PV and neurological disorders is unclear and needs to be more studied. Here, we report a case of amyotrophic lateral sclerosis (ALS),...
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doaj-dc55a4d6f7844a78861e95096302efe82020-11-24T23:48:08ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362016-01-01211828210.4103/1735-1995.192498Pemphigus vulgaris and amyotrophic lateral sclerosisFatemeh MokhtariMarzieh MatinFatemeh RajatiPemphigus vulgaris (PV) is an autoimmune bullous and erosive mucocutaneous disease. Rarely, it occurs in patients with other autoimmune disease. The relation between PV and neurological disorders is unclear and needs to be more studied. Here, we report a case of amyotrophic lateral sclerosis (ALS), followed by dermatologic involvement. Histopathological evidence and direct immunofluorescence are consistent with PV. Systemic corticosteroid and azathioprine were effective in the treatment of mucocutaneous lesions. PV seems to be accidentally associated with ALS. Expression of major histocompatibility complex Class II in autoimmune disease and production of autoantibodies have been proposed to describe the association of PV with ALS.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2016;volume=21;issue=1;spage=82;epage=82;aulast=MokhtariAmyotrophic lateral sclerosismajor histocompatibility complex Class IIpemphigus vulgaris |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fatemeh Mokhtari Marzieh Matin Fatemeh Rajati |
spellingShingle |
Fatemeh Mokhtari Marzieh Matin Fatemeh Rajati Pemphigus vulgaris and amyotrophic lateral sclerosis Journal of Research in Medical Sciences Amyotrophic lateral sclerosis major histocompatibility complex Class II pemphigus vulgaris |
author_facet |
Fatemeh Mokhtari Marzieh Matin Fatemeh Rajati |
author_sort |
Fatemeh Mokhtari |
title |
Pemphigus vulgaris and amyotrophic lateral sclerosis |
title_short |
Pemphigus vulgaris and amyotrophic lateral sclerosis |
title_full |
Pemphigus vulgaris and amyotrophic lateral sclerosis |
title_fullStr |
Pemphigus vulgaris and amyotrophic lateral sclerosis |
title_full_unstemmed |
Pemphigus vulgaris and amyotrophic lateral sclerosis |
title_sort |
pemphigus vulgaris and amyotrophic lateral sclerosis |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Research in Medical Sciences |
issn |
1735-1995 1735-7136 |
publishDate |
2016-01-01 |
description |
Pemphigus vulgaris (PV) is an autoimmune bullous and erosive mucocutaneous disease. Rarely, it occurs in patients with other autoimmune disease. The relation between PV and neurological disorders is unclear and needs to be more studied. Here, we report a case of amyotrophic lateral sclerosis (ALS), followed by dermatologic involvement. Histopathological evidence and direct immunofluorescence are consistent with PV. Systemic corticosteroid and azathioprine were effective in the treatment of mucocutaneous lesions. PV seems to be accidentally associated with ALS. Expression of major histocompatibility complex Class II in autoimmune disease and production of autoantibodies have been proposed to describe the association of PV with ALS. |
topic |
Amyotrophic lateral sclerosis major histocompatibility complex Class II pemphigus vulgaris |
url |
http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2016;volume=21;issue=1;spage=82;epage=82;aulast=Mokhtari |
work_keys_str_mv |
AT fatemehmokhtari pemphigusvulgarisandamyotrophiclateralsclerosis AT marziehmatin pemphigusvulgarisandamyotrophiclateralsclerosis AT fatemehrajati pemphigusvulgarisandamyotrophiclateralsclerosis |
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1725487102780506112 |