Trends and associated characteristics for Chagas disease among women of reproductive age in the United States, 2002 to 2017
Background: American trypanosomiasis, commonly referred to as Chagas disease, is caused by a single cell protozoan known as Trypanosoma cruzi (T. cruzi). Although those affected are mainly in Latin America, Chagas has been detected in the United States (US), Canada and in many European countries due...
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Format: | Article |
Language: | English |
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Elsevier
2020-11-01
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Series: | Parasite Epidemiology and Control |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2405673120300362 |
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doaj-dc55f80d399448928a2eca4d09ccddc8 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chioma Ikedionwu Deepa Dongarwar Manvir Kaur Lisa Nunez Annabella Awazi Jere' Mallet KaShena Kennedy Michelle Cano Chinwe Dike Jessica Okwudi Justice Stewart David Igwegbe Flora G. Estes Kiara K. Spooner Jason L. Salemi Hamisu M. Salihu Omonike A. Olaleye |
spellingShingle |
Chioma Ikedionwu Deepa Dongarwar Manvir Kaur Lisa Nunez Annabella Awazi Jere' Mallet KaShena Kennedy Michelle Cano Chinwe Dike Jessica Okwudi Justice Stewart David Igwegbe Flora G. Estes Kiara K. Spooner Jason L. Salemi Hamisu M. Salihu Omonike A. Olaleye Trends and associated characteristics for Chagas disease among women of reproductive age in the United States, 2002 to 2017 Parasite Epidemiology and Control Neglected disease Chagas disease Ethnic/racial disparities United States Reproductive health HCUP |
author_facet |
Chioma Ikedionwu Deepa Dongarwar Manvir Kaur Lisa Nunez Annabella Awazi Jere' Mallet KaShena Kennedy Michelle Cano Chinwe Dike Jessica Okwudi Justice Stewart David Igwegbe Flora G. Estes Kiara K. Spooner Jason L. Salemi Hamisu M. Salihu Omonike A. Olaleye |
author_sort |
Chioma Ikedionwu |
title |
Trends and associated characteristics for Chagas disease among women of reproductive age in the United States, 2002 to 2017 |
title_short |
Trends and associated characteristics for Chagas disease among women of reproductive age in the United States, 2002 to 2017 |
title_full |
Trends and associated characteristics for Chagas disease among women of reproductive age in the United States, 2002 to 2017 |
title_fullStr |
Trends and associated characteristics for Chagas disease among women of reproductive age in the United States, 2002 to 2017 |
title_full_unstemmed |
Trends and associated characteristics for Chagas disease among women of reproductive age in the United States, 2002 to 2017 |
title_sort |
trends and associated characteristics for chagas disease among women of reproductive age in the united states, 2002 to 2017 |
publisher |
Elsevier |
series |
Parasite Epidemiology and Control |
issn |
2405-6731 |
publishDate |
2020-11-01 |
description |
Background: American trypanosomiasis, commonly referred to as Chagas disease, is caused by a single cell protozoan known as Trypanosoma cruzi (T. cruzi). Although those affected are mainly in Latin America, Chagas has been detected in the United States (US), Canada and in many European countries due to migration. Few studies have explored the epidemiology of Chagas within the US or changes in disease burden over the past decade. The objective of this study was to explore the trends and associated characteristics for Chagas disease among hospitalized women of reproductive age in the US. Methods: We analyzed admissions data including socio-demographic and hospital characteristics for inpatient hospitalization for women of reproductive age (15–49 years) in the US from 2002 through 2017. We employed Joinpoint regression analysis to determine trends in the prevalence of Chagas disease over this period. Results: A total of 487 hospitalizations of Chagas disease were identified, corresponding to 3.7 per million hospitalizations over the study period. The rate statistically increased from 1.6 per million in 2002 to 7.6 per million hospitalizations in 2017. Chagas was most prevalent among older women, Hispanics and those in the highest zip income bracket. The in-hospital mortality rate was about 10 times greater among women with Chagas compared to those without the condition (3.1% versus 0.3%), and the condition tended to be clustered in women treated at large, urban teaching hospitals in the Northeastern region of the US. Conclusion: Chagas disease diagnosis appears to be increasing among hospitalized women of reproductive age in the US with a 10-fold elevated risk of mortality. |
topic |
Neglected disease Chagas disease Ethnic/racial disparities United States Reproductive health HCUP |
url |
http://www.sciencedirect.com/science/article/pii/S2405673120300362 |
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doaj-dc55f80d399448928a2eca4d09ccddc82020-12-27T04:30:43ZengElsevierParasite Epidemiology and Control2405-67312020-11-0111e00167Trends and associated characteristics for Chagas disease among women of reproductive age in the United States, 2002 to 2017Chioma Ikedionwu0Deepa Dongarwar1Manvir Kaur2Lisa Nunez3Annabella Awazi4Jere' Mallet5KaShena Kennedy6Michelle Cano7Chinwe Dike8Jessica Okwudi9Justice Stewart10David Igwegbe11Flora G. Estes12Kiara K. Spooner13Jason L. Salemi14Hamisu M. Salihu15Omonike A. Olaleye16Center of Excellence in Health Equity, Training, and Research, Baylor College of Medicine, Houston, TX, USACenter of Excellence in Health Equity, Training, and Research, Baylor College of Medicine, Houston, TX, USA; Corresponding author at: Center of Excellence in Health Equity, Training, and Research, Baylor College of Medicine, 3701 Kirby Drive, Houston, TX 77098, USA.College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USACollege of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USACollege of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USACollege of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USACollege of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USACollege of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USACollege of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USACollege of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USACollege of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USACollege of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USACollege of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USADepartment of Family and Community Medicine, Baylor College of Medicine, Houston, TX, USADepartment of Family and Community Medicine, Baylor College of Medicine, Houston, TX, USACenter of Excellence in Health Equity, Training, and Research, Baylor College of Medicine, Houston, TX, USA; Department of Family and Community Medicine, Baylor College of Medicine, Houston, TX, USACollege of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USABackground: American trypanosomiasis, commonly referred to as Chagas disease, is caused by a single cell protozoan known as Trypanosoma cruzi (T. cruzi). Although those affected are mainly in Latin America, Chagas has been detected in the United States (US), Canada and in many European countries due to migration. Few studies have explored the epidemiology of Chagas within the US or changes in disease burden over the past decade. The objective of this study was to explore the trends and associated characteristics for Chagas disease among hospitalized women of reproductive age in the US. Methods: We analyzed admissions data including socio-demographic and hospital characteristics for inpatient hospitalization for women of reproductive age (15–49 years) in the US from 2002 through 2017. We employed Joinpoint regression analysis to determine trends in the prevalence of Chagas disease over this period. Results: A total of 487 hospitalizations of Chagas disease were identified, corresponding to 3.7 per million hospitalizations over the study period. The rate statistically increased from 1.6 per million in 2002 to 7.6 per million hospitalizations in 2017. Chagas was most prevalent among older women, Hispanics and those in the highest zip income bracket. The in-hospital mortality rate was about 10 times greater among women with Chagas compared to those without the condition (3.1% versus 0.3%), and the condition tended to be clustered in women treated at large, urban teaching hospitals in the Northeastern region of the US. Conclusion: Chagas disease diagnosis appears to be increasing among hospitalized women of reproductive age in the US with a 10-fold elevated risk of mortality.http://www.sciencedirect.com/science/article/pii/S2405673120300362Neglected diseaseChagas diseaseEthnic/racial disparitiesUnited StatesReproductive healthHCUP |