A rare case of pulmonary mycobacteriosis caused by rifabutin resistant Mycobacterium celatum and review of the literature
The present case demonstrates an atypical pulmonary mycobacteriosis that mimicked classical symptoms and radiology findings for tuberculosis. While T-SPOT Test and PCR analyses proved negative for tuberculosis, microscopic sputum evaluation showed acid-fast bacilli and Mycobacterium celatum was foun...
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doaj-dc5a87a519554b4eaffced7d94dbf30f2020-11-25T02:12:22ZengElsevierRespiratory Medicine Case Reports2213-00712019-01-0128A rare case of pulmonary mycobacteriosis caused by rifabutin resistant Mycobacterium celatum and review of the literatureMarcela Doktorova Demmin0Adrian Gillissen1Corresponding author. Department of Internal Medicine III (Internal and Pulmonary Medicine), Kreiskliniken Reutlingen/Ermstalklinik, Stuttgarterstr. 100, D-72574, Bad Urach, Germany.; Department of Internal Medicine III (Internal and Pulmonary Medicine), Ermstalklinik of Kreisklinikum Reutlingen, Stuttgarterstr. 100, D-72574, Bad Urach, GermanyDepartment of Internal Medicine III (Internal and Pulmonary Medicine), Ermstalklinik of Kreisklinikum Reutlingen, Stuttgarterstr. 100, D-72574, Bad Urach, GermanyThe present case demonstrates an atypical pulmonary mycobacteriosis that mimicked classical symptoms and radiology findings for tuberculosis. While T-SPOT Test and PCR analyses proved negative for tuberculosis, microscopic sputum evaluation showed acid-fast bacilli and Mycobacterium celatum was found in culture. Uniquely, in our case M. celatum was resistant to rifabutin. Therefore, after not responding to combination treatment including rifabutin, our patient was treated with ethambutol, clarithromycin and protionamide. Classical risk factors for atypical mycobacteriosis such as immunodeficiency (including medication-induced), preexisting pulmonary disease or multimorbidity were not present. We conclude that the high age of the patient (92 y) may have been the main contributing factor for the infection. Keywords: Mycobacterium celatum, Cavity, Atypical mycobacterial infection, Rifabutin, Resistancehttp://www.sciencedirect.com/science/article/pii/S2213007119300905 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marcela Doktorova Demmin Adrian Gillissen |
spellingShingle |
Marcela Doktorova Demmin Adrian Gillissen A rare case of pulmonary mycobacteriosis caused by rifabutin resistant Mycobacterium celatum and review of the literature Respiratory Medicine Case Reports |
author_facet |
Marcela Doktorova Demmin Adrian Gillissen |
author_sort |
Marcela Doktorova Demmin |
title |
A rare case of pulmonary mycobacteriosis caused by rifabutin resistant Mycobacterium celatum and review of the literature |
title_short |
A rare case of pulmonary mycobacteriosis caused by rifabutin resistant Mycobacterium celatum and review of the literature |
title_full |
A rare case of pulmonary mycobacteriosis caused by rifabutin resistant Mycobacterium celatum and review of the literature |
title_fullStr |
A rare case of pulmonary mycobacteriosis caused by rifabutin resistant Mycobacterium celatum and review of the literature |
title_full_unstemmed |
A rare case of pulmonary mycobacteriosis caused by rifabutin resistant Mycobacterium celatum and review of the literature |
title_sort |
rare case of pulmonary mycobacteriosis caused by rifabutin resistant mycobacterium celatum and review of the literature |
publisher |
Elsevier |
series |
Respiratory Medicine Case Reports |
issn |
2213-0071 |
publishDate |
2019-01-01 |
description |
The present case demonstrates an atypical pulmonary mycobacteriosis that mimicked classical symptoms and radiology findings for tuberculosis. While T-SPOT Test and PCR analyses proved negative for tuberculosis, microscopic sputum evaluation showed acid-fast bacilli and Mycobacterium celatum was found in culture. Uniquely, in our case M. celatum was resistant to rifabutin. Therefore, after not responding to combination treatment including rifabutin, our patient was treated with ethambutol, clarithromycin and protionamide. Classical risk factors for atypical mycobacteriosis such as immunodeficiency (including medication-induced), preexisting pulmonary disease or multimorbidity were not present. We conclude that the high age of the patient (92 y) may have been the main contributing factor for the infection. Keywords: Mycobacterium celatum, Cavity, Atypical mycobacterial infection, Rifabutin, Resistance |
url |
http://www.sciencedirect.com/science/article/pii/S2213007119300905 |
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