CIRCULATING HAEMOGLOBIN LEVELS AND THE RISK OF ATHEROSCLEROSIS IN ASIAN INDIAN POPULATIONS
Background: The global burden of coronary heart disease (CHD) is estimated to be the highest on the Indian subcontinent. The pathophysiology of this increased risk is complex, multifactorial, and its magnitude increases with migration from India to Britain. Haemoglobin disorders, which also frequen...
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European Medical Journal
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doaj-dc65d53f5c78456e8eaee7d4c04e075a2020-11-25T03:58:59ZengEuropean Medical JournalEuropean Medical Journal Cardiology2054-31742015-02-01315866CIRCULATING HAEMOGLOBIN LEVELS AND THE RISK OF ATHEROSCLEROSIS IN ASIAN INDIAN POPULATIONSJeetesh V. Patel0Paul J. Flinders1Avni Vyas2Imogen Glover3Avithra J. Rajan4Dorairaj Prabhakaran5Deepak Bhatnagar6K. Srinath Reddy7Michael I. Mackness8J. Kennedy Cruickshank9Elizabeth A. Hughes10Paul N. Durrington11Clinical Epidemiology & Cardiovascular Medicine Group, University Department of Medicine, University of Manchester, Manchester, UKSchool of Medicine, University of Nottingham, Nottingham, UKClinical Epidemiology & Cardiovascular Medicine Group, University Department of Medicine, University of Manchester, Manchester, UKSchool of Medicine, University of Nottingham, Nottingham, UKSchool of Medicine, University of Nottingham, Nottingham, UKDepartment of Cardiology, All India Institute of Medical Sciences, Delhi, IndiaClinical Epidemiology & Cardiovascular Medicine Group, University Department of Medicine, University of Manchester, Manchester, UK Department of Cardiology, All India Institute of Medical Sciences, Delhi, IndiaClinical Epidemiology & Cardiovascular Medicine Group, University Department of Medicine, University of Manchester, Manchester, UKClinical Epidemiology & Cardiovascular Medicine Group, University Department of Medicine, University of Manchester, Manchester, UKSandwell Medical Research Unit, Sandwell and West Birmingham Hospitals NHS Trust, West Bromwich, UKClinical Epidemiology & Cardiovascular Medicine Group, University Department of Medicine, University of Manchester, Manchester, UKBackground: The global burden of coronary heart disease (CHD) is estimated to be the highest on the Indian subcontinent. The pathophysiology of this increased risk is complex, multifactorial, and its magnitude increases with migration from India to Britain. Haemoglobin disorders, which also frequent this ethnic group, have been linked to cardiovascular disease. We investigated the impact of migration and nutritional intake on haematological parameters amongst South Asians, with a focus on their relation to molecular indices of oxidative atherogenesis. Methods: Haematology, diet, oxidised low-density lipoprotein (LDL), and serum paraoxonase activity were measured in 230 migrant Indian Gujaratis (Britain), and 305 matched contemporaries living in rural villages (India). Results: Median levels of haemoglobin were higher amongst migrant men (14.5 µmol/l) compared to rural men (15.0 µmol/l, P=0.004) and higher in migrant women (12.7 µmol/l) compared to rural women (11.8 µmol/l, P<0.001). Irrespective of site, haemoglobin levels in South Asians were positively associated with high blood pressure, high serum cholesterol, low high density lipoprotein (HDL) cholesterol levels, and increased CHD risk scores (P<0.001). Haemoglobin concentrations were higher amongst migrants compared to rural contemporaries (P<0.001). In rural women, red cell volume was lower, and co-ordinated with lower levels of oxidised LDL compared with migrant women (P<0.001). On multivariate analysis, haemoglobin was independently associated with oxidised LDL (P=0.001) and paraoxonase activity (P=0.025). Conclusion: Levels of haemoglobin were independently associated with indices of atherogenesis in our populations of rural and migrant Indians. Iron availability may underline the pathogenesis for the oxidative modification of LDL in this group.https://www.emjreviews.com/cardiology/article/circulating-haemoglobin-levels-and-the-risk-of-atherosclerosis-in-asian-indian-populations/coronary heart disease (chd)low-density lipoproteinhigh density lipoprotein (hdl)atherogenesisoxidative modificationcirculating haemoglobinatherosclerosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jeetesh V. Patel Paul J. Flinders Avni Vyas Imogen Glover Avithra J. Rajan Dorairaj Prabhakaran Deepak Bhatnagar K. Srinath Reddy Michael I. Mackness J. Kennedy Cruickshank Elizabeth A. Hughes Paul N. Durrington |
spellingShingle |
Jeetesh V. Patel Paul J. Flinders Avni Vyas Imogen Glover Avithra J. Rajan Dorairaj Prabhakaran Deepak Bhatnagar K. Srinath Reddy Michael I. Mackness J. Kennedy Cruickshank Elizabeth A. Hughes Paul N. Durrington CIRCULATING HAEMOGLOBIN LEVELS AND THE RISK OF ATHEROSCLEROSIS IN ASIAN INDIAN POPULATIONS European Medical Journal Cardiology coronary heart disease (chd) low-density lipoprotein high density lipoprotein (hdl) atherogenesis oxidative modification circulating haemoglobin atherosclerosis |
author_facet |
Jeetesh V. Patel Paul J. Flinders Avni Vyas Imogen Glover Avithra J. Rajan Dorairaj Prabhakaran Deepak Bhatnagar K. Srinath Reddy Michael I. Mackness J. Kennedy Cruickshank Elizabeth A. Hughes Paul N. Durrington |
author_sort |
Jeetesh V. Patel |
title |
CIRCULATING HAEMOGLOBIN LEVELS AND THE RISK OF ATHEROSCLEROSIS IN ASIAN INDIAN POPULATIONS |
title_short |
CIRCULATING HAEMOGLOBIN LEVELS AND THE RISK OF ATHEROSCLEROSIS IN ASIAN INDIAN POPULATIONS |
title_full |
CIRCULATING HAEMOGLOBIN LEVELS AND THE RISK OF ATHEROSCLEROSIS IN ASIAN INDIAN POPULATIONS |
title_fullStr |
CIRCULATING HAEMOGLOBIN LEVELS AND THE RISK OF ATHEROSCLEROSIS IN ASIAN INDIAN POPULATIONS |
title_full_unstemmed |
CIRCULATING HAEMOGLOBIN LEVELS AND THE RISK OF ATHEROSCLEROSIS IN ASIAN INDIAN POPULATIONS |
title_sort |
circulating haemoglobin levels and the risk of atherosclerosis in asian indian populations |
publisher |
European Medical Journal |
series |
European Medical Journal Cardiology |
issn |
2054-3174 |
publishDate |
2015-02-01 |
description |
Background: The global burden of coronary heart disease (CHD) is estimated to be the highest on the Indian subcontinent. The pathophysiology of this increased risk is complex, multifactorial, and its magnitude increases with migration from India to Britain. Haemoglobin disorders, which also frequent this ethnic group, have been linked to cardiovascular disease. We investigated the impact of migration and nutritional intake on haematological parameters amongst South Asians, with a focus on their relation to molecular indices of oxidative atherogenesis.
Methods: Haematology, diet, oxidised low-density lipoprotein (LDL), and serum paraoxonase activity were measured in 230 migrant Indian Gujaratis (Britain), and 305 matched contemporaries living in rural villages (India).
Results: Median levels of haemoglobin were higher amongst migrant men (14.5 µmol/l) compared to rural men (15.0 µmol/l, P=0.004) and higher in migrant women (12.7 µmol/l) compared to rural women (11.8 µmol/l, P<0.001). Irrespective of site, haemoglobin levels in South Asians were positively associated with high blood pressure, high serum cholesterol, low high density lipoprotein (HDL) cholesterol levels, and increased CHD risk scores (P<0.001). Haemoglobin concentrations were higher amongst migrants compared to rural contemporaries (P<0.001). In rural women, red cell volume was lower, and co-ordinated with lower levels of oxidised LDL compared with migrant women (P<0.001). On multivariate analysis, haemoglobin was independently associated with oxidised LDL (P=0.001) and paraoxonase activity (P=0.025).
Conclusion: Levels of haemoglobin were independently associated with indices of atherogenesis in our populations of rural and migrant Indians. Iron availability may underline the pathogenesis for the oxidative modification of LDL in this group. |
topic |
coronary heart disease (chd) low-density lipoprotein high density lipoprotein (hdl) atherogenesis oxidative modification circulating haemoglobin atherosclerosis |
url |
https://www.emjreviews.com/cardiology/article/circulating-haemoglobin-levels-and-the-risk-of-atherosclerosis-in-asian-indian-populations/ |
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