Outer Membrane Vesicle Biosynthesis in Salmonella: Is There More to Gram-Negative Bacteria?

Recent research has focused on the biological role of outer membrane vesicles (OMVs), which are derived from the outer membranes (OMs) of Gram-negative bacteria, and their potential exploitation as therapeutics. OMVs have been characterized in many ways and functions. Until recently, research focuse...

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Main Author: Joachim Reidl
Format: Article
Language:English
Published: American Society for Microbiology 2016-08-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/7/4/e01282-16
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spelling doaj-dc7823daa1c74847957987e648de81f82021-07-02T07:33:58ZengAmerican Society for MicrobiologymBio2150-75112016-08-0174e01282-1610.1128/mBio.01282-16Outer Membrane Vesicle Biosynthesis in Salmonella: Is There More to Gram-Negative Bacteria?Joachim ReidlRecent research has focused on the biological role of outer membrane vesicles (OMVs), which are derived from the outer membranes (OMs) of Gram-negative bacteria, and their potential exploitation as therapeutics. OMVs have been characterized in many ways and functions. Until recently, research focused on hypothetical and empirical models that addressed the molecular mechanisms of OMV biogenesis, such as vesicles bulging from the OM in various ways. The recently reported study by Elhenawy et al. (mBio 7:e00940-16, 2016, http://dx.doi.org/10.1128/mBio.00940-16) provided further insights into OMV biogenesis of Salmonella enterica serovar Typhimurium. That study showed that deacylation of lipopolysaccharides (LPS) influences the level of OMV production and, furthermore, determines a sorting of high versus low acylated LPS in OMs and OMVs, respectively. Interestingly, deacylation may inversely correlate with other LPS modifications, suggesting some synergy toward optimized host resistance via best OM compositions for S. Typhimurium.http://mbio.asm.org/cgi/content/full/7/4/e01282-16
collection DOAJ
language English
format Article
sources DOAJ
author Joachim Reidl
spellingShingle Joachim Reidl
Outer Membrane Vesicle Biosynthesis in Salmonella: Is There More to Gram-Negative Bacteria?
mBio
author_facet Joachim Reidl
author_sort Joachim Reidl
title Outer Membrane Vesicle Biosynthesis in Salmonella: Is There More to Gram-Negative Bacteria?
title_short Outer Membrane Vesicle Biosynthesis in Salmonella: Is There More to Gram-Negative Bacteria?
title_full Outer Membrane Vesicle Biosynthesis in Salmonella: Is There More to Gram-Negative Bacteria?
title_fullStr Outer Membrane Vesicle Biosynthesis in Salmonella: Is There More to Gram-Negative Bacteria?
title_full_unstemmed Outer Membrane Vesicle Biosynthesis in Salmonella: Is There More to Gram-Negative Bacteria?
title_sort outer membrane vesicle biosynthesis in salmonella: is there more to gram-negative bacteria?
publisher American Society for Microbiology
series mBio
issn 2150-7511
publishDate 2016-08-01
description Recent research has focused on the biological role of outer membrane vesicles (OMVs), which are derived from the outer membranes (OMs) of Gram-negative bacteria, and their potential exploitation as therapeutics. OMVs have been characterized in many ways and functions. Until recently, research focused on hypothetical and empirical models that addressed the molecular mechanisms of OMV biogenesis, such as vesicles bulging from the OM in various ways. The recently reported study by Elhenawy et al. (mBio 7:e00940-16, 2016, http://dx.doi.org/10.1128/mBio.00940-16) provided further insights into OMV biogenesis of Salmonella enterica serovar Typhimurium. That study showed that deacylation of lipopolysaccharides (LPS) influences the level of OMV production and, furthermore, determines a sorting of high versus low acylated LPS in OMs and OMVs, respectively. Interestingly, deacylation may inversely correlate with other LPS modifications, suggesting some synergy toward optimized host resistance via best OM compositions for S. Typhimurium.
url http://mbio.asm.org/cgi/content/full/7/4/e01282-16
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