Differential Activity of the Combination of Vancomycin and Amikacin on Planktonic vs. Biofilm-Growing Staphylococcus aureus Bacteria in a Hollow Fiber Infection Model

Differential Activity of the Combination of Vancomycin and Amikacin on Planktonic vs. Biofilm-Growing Staphylococcus aureus Bacteria in a Hollow Fiber Infection Model

Combining currently available antibiotics to optimize their use is a promising strategy to reduce treatment failures against biofilm-associated infections. Nevertheless, most assays of such combinations have been performed in vitro on planktonic bacteria exposed to constant concentrations of antibio...

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Bibliographic Details
Main Authors: Diane C. Broussou, Marlène Z. Lacroix, Pierre-Louis Toutain, Frédérique Woehrlé, Farid El Garch, Alain Bousquet-Melou, Aude A. Ferran
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Microbiology
Subjects:
hollow-fiber infection model
antibiotic combination
amikacin
vancomycin
biofilm
antimicrobial resistance
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00572/full

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