Rescue of premature aging defects in Cockayne syndrome stem cells by CRISPR/Cas9-mediated gene correction

Rescue of premature aging defects in Cockayne syndrome stem cells by CRISPR/Cas9-mediated gene correction

Abstract Cockayne syndrome (CS) is a rare autosomal recessive inherited disorder characterized by a variety of clinical features, including increased sensitivity to sunlight, progressive neurological abnormalities, and the appearance of premature aging. However, the pathogenesis of CS remains unclea...

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Bibliographic Details
Main Authors: Si Wang, Zheying Min, Qianzhao Ji, Lingling Geng, Yao Su, Zunpeng Liu, Huifang Hu, Lixia Wang, Weiqi Zhang, Keiichiro Suzuiki, Yu Huang, Puyao Zhang, Tie-Shan Tang, Jing Qu, Yang Yu, Guang-Hui Liu, Jie Qiao
Format: Article
Language:English
Published: SpringerOpen 2019-04-01
Series:Protein & Cell
Subjects:
Cockayne syndrome
CRISPR/Cas9
gene correction
disease modelling
mesenchymal stem cell
neural stem cell
Online Access:http://link.springer.com/article/10.1007/s13238-019-0623-2

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